MLN-4760
MLN-4760 Basic information
- Product Name:
- MLN-4760
- Synonyms:
-
- MLN-4760
- L-Histidine, N-[(1S)-1-carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-
- ((S)-1-carboxy-2-(1-(3,5-dichlorobenzyl)-1H-imidazol-5-yl)ethyl)-L-leucine
- inhibit,Angiotensin-converting Enzyme (ACE),MLN 4760,Inhibitor,MLN-4760,MLN4760
- (2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dichlorophenyl)methyl]-1H-imidazol-5-yl}ethyl]amino}-4-methylpentanoic acid
- CAS:
- 305335-31-3
- MF:
- C19H23Cl2N3O4
- MW:
- 428.31
- Mol File:
- 305335-31-3.mol
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MLN-4760 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A solid
- color
- Off-white to light yellow
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MLN-4760 Usage And Synthesis
Definition
ChEBI: MLN-4760 is a L-histidine derivative that is L-histidine in which a hydrogen of the primary amino group is substituted by a (1S)-1-carboxy-3-methylbutyl group and the ring NH group is substituted by a 3,5-dichlorobenzyl group. It is a potent and selective human angiotensin-converting enzyme 2 (ACE2) inhibitor (IC50 = 0.44 nM) which was in clinical development for the treatment of ulcerative colitis. It has a role as an anti-inflammatory agent and an EC 3.4.17.23 (angiotensin-converting enzyme 2) inhibitor. It is a L-histidine derivative, a dichlorobenzene and a L-leucine derivative.
storage
Store at -20°C
MLN-4760Supplier
Shanghai Luofa Biochemical Technology Co., Ltd. Gold
- Tel
- 021-51111890 15317326293
- sales@molnova.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
ChemStrong Scientific Co.,Ltd
- Tel
- 0755-0755-66853366 13670046396
- sales@chem-strong.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com