5,15-DIPHENYL-21H,23H-PORPHINE
5,15-DIPHENYL-21H,23H-PORPHINE Basic information
- Product Name:
- 5,15-DIPHENYL-21H,23H-PORPHINE
- Synonyms:
-
- 5,15-DIPHENYL-21H,23H-PORPHINE
- 5,15-DIPHENYLPORPHINE
- 5, 15-BIS-(PHENYL)PORPHYRINS
- 5,15-Diphenylporphyrin
- STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem
- 10,20-diphenyl-21,22-dihydroporphyrin
- 5,15-Bis-(phenyl)-21H,23H-porphyrins
- 5,15-DPP
- CAS:
- 22112-89-6
- MF:
- C32H22N4
- MW:
- 462.54
- Product Categories:
-
- Biochemistry
- Porphyrins
- Mol File:
- 22112-89-6.mol
5,15-DIPHENYL-21H,23H-PORPHINE Chemical Properties
- Melting point:
- >200℃
- Boiling point:
- 912.3±65.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- ≤2mg/ml in dimethyl formamide
- form
- Deep blue to deep purple solid
- color
- Red to Dark blue to Black
5,15-DIPHENYL-21H,23H-PORPHINE Usage And Synthesis
Uses
5,15-Diphenylporphyrin (cas# 22112-89-6) is a useful research chemical.
Biological Activity
5,15-diphenylporphyrin (5,15-dpp) is a selective stat3-sh2 antagonist [1].stat3 is constitutively activated in many human cancers. stat3 functions as a critical mediator of oncogenic signaling through transcriptional activation of genes encoding apoptosis inhibitors, cell-cycle regulators and inducers of angiogenesis [2]. aberrant stat3 activity has been associated with transforming mechanisms induced by oncogenic tyrosine kinases [1].
in vitro
5,15-dpp directly bound to stat3 and antagonized the function of stat3-sh2. 5,15-dpp selectively antagonized stat3-sh2 with an ic50 of 0.28 μm over the other sh2-containing proteins stat1 and grb2[1]. the estimated kd values for the 5,15-dpp binding to stat3 was 880 nm. treatment with 5,15-dpp suppressed the dna binding activity of stat3 in a concentration-dependent manner. 5,15-dpp poorly inhibited stat1 with an ic50 of 10 μm and showed no effect grb2 [1].
References
[1] uehara y, mochizuki m, matsuno k, et al. novel high-throughput screening system for identifying stat3–sh2 antagonists[j]. biochemical and biophysical research communications, 2009, 380(3): 627-631.
[2] jing n, tweardy d j. targeting stat3 in cancer therapy[j]. anti-cancer drugs, 2005, 16(6): 601-607.
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