METHDILAZINE (200 MG) Chemical Properties

Melting point:

87-88℃

Boiling point:

170 °C(Press: 0.04 Torr)

Density 

1.185

refractive index 

1.6000 (estimate)

pka

pKa 7.45 (Uncertain)

EPA Substance Registry System

Methdilazine (1982-37-2)

METHDILAZINE (200 MG) Usage And Synthesis

Originator

Tacaryl ,Westwood,US,1960

Uses

Antipruritic.

Definition

ChEBI: Methdilazine is a phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties. It has a role as a histamine antagonist, a cholinergic antagonist and an antipruritic drug. It is a member of phenothiazines and a N-alkylpyrrolidine.

Manufacturing Process

10.8 parts of 10-(1-methyl-3-pyrrolidylmethyl) phenothiazine (prepared from 1-methyl-3-pyrrolidylmethyl chloride by reaction with phenothiazine) in 80 parts of 99% isopropyl alcohol were treated with a solution of 1.33 parts of hydrogen chloride in 30 parts of the same solvent. The clear light yellow solution soon deposited white crystals of the acid addition salt. After cooling overnight at 0°C, the crystalline product was collected on a filter, washed with 99% isopropyl alcohol and anhydrous ether and then dried in a vacuum oven at 95°C. Yield 10.4 parts, MP 187.5° to 189°C.

brand name

Tacaryl (Westwood-Squibb).

Therapeutic Function

Antipruritic

General Description

Methdilazine, 10-[(1-methyl-3-pyrrolidinyl)methyl]phenothiazine (Tacaryl), is a light-tan crystallinepowder that has a characteristic odor and is practicallyinsoluble in water. Methdilazine, as the free base, isused in chewable tablets because its low solubility in watercontributes to its tastelessness. Some local anesthesia of thebuccal mucosa may be experienced if the tablet is chewedand not swallowed promptly.

General Description

Crystals.

Reactivity Profile

METHDILAZINE (200 MG) is sensitive to light. .

Health Hazard

SYMPTOMS: Symptoms of exposure to METHDILAZINE (200 MG) may include drowsiness, hypotension, tachycardia, dryness of the mouth, nausea, nasal congestion, fever and tremors.

Fire Hazard

Flash point data for METHDILAZINE (200 MG) are not available. METHDILAZINE (200 MG) is probably combustible.

METHDILAZINE (200 MG)(1982-37-2)Related Product Information

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• Phenothiazine
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• METHDILAZINE (200 MG)
• METHDILAZINE HYDROCHLORIDE (200 MG),METHDILAZINE HCL