Trimeprazine Chemical Properties

Melting point:

68°C

Boiling point:

bp0.3 150-175°

Density 

1.1163 (rough estimate)

refractive index 

1.6000 (estimate)

pka

pKa 9.00 (Uncertain)

Water Solubility 

0.942 mg/L

CAS DataBase Reference

84-96-8

NIST Chemistry Reference

Trimeprazine(84-96-8)

Safety Information

Hazardous Substances Data

84-96-8(Hazardous Substances Data)

MSDS

• Language:English Provider:Alimemazine

Trimeprazine Usage And Synthesis

Originator

Temaril,SKF,US,1958

Uses

antipruritic

Uses

Trimeprazine is used for treating itching during dermatitis of both allergic and nonallergic origin.

Definition

ChEBI: Trimeprazine is a member of phenothiazines.

Manufacturing Process

95% sodamide (2.77 grams) is added to a solution of phenthiazine (9.6 grams) in xylene (140 cc) at a temperature of 130°C and the mixture is heated with reflux for 2 hours.
A 0.61 N solution (90 cc) of 1-chloro-2-methyl-3-dimethylaminopropane in xylene is then added over 50 minutes and heating with reflux is continued for 20 hours. After cooling, the mixture is treated with water (40 cc) and N methanesulfonic acid (70 cc). The aqueous layer is washed with ether, treated with aqueous sodium hydroxide (density = 1.33; 10 cc) and extracted with ether.
The extract is dried over potassium carbonate and evaporated and the residue is distilled in vacuo. 3-(10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (12.6 grams) is collected, distilling between 150° and 175°C under a pressure of about 0.3 mm Hg. By dissolving this base in acetone and adding ethereal hydrogen chloride, a hydrochloride is obtained, MP 216° to 217°C.

brand name

Temaril (Allergan).

Therapeutic Function

Antipruritic

Trimeprazine(84-96-8)Related Product Information

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• (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
• MEQUITAZINE
• pecazine
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• OXOMEMAZINE
• methiomeprazine
• cyamemazine
• perimetazine
• Levomepromazine hydrochloride
• Trimeprazine tartrate
• (-)-2-[METHYLAMINO]-1-PHENYLPROPANE
• 2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol
• Phenothiazine