Trimeprazine tartrate
Trimeprazine tartrate Basic information
- Product Name:
- Trimeprazine tartrate
- Synonyms:
-
- 10-(3-(dimethylamino)-2-methylpropyl)phenothiazinetartrate
- 10-(3-(dimethylamino)-2-methylpropyl)-phenothiazintartrate(2:1)
- panectyl
- repeltin
- temaril
- theralene
- vallergan
- n,n,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine tartrate
- CAS:
- 4330-99-8
- MF:
- C22H28N2O6S
- MW:
- 448.53
- EINECS:
- 224-368-9
- Product Categories:
-
- Amines
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Mol File:
- 4330-99-8.mol
Trimeprazine tartrate Chemical Properties
- Melting point:
- 153-155°C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): insol
- form
- Solid
- color
- White to Almost white
- Merck
- 14,9704
- InChIKey
- ZEEPCWVFSHMOPI-MVELKYERNA-N
- SMILES
- C(N1C2=CC=CC=C2SC2C=CC=CC1=2)C(C)CN(C)C.[C@H](O)(C(=O)O)[C@@H](O)C(=O)O |&1:21,26,r|
- CAS DataBase Reference
- 4330-99-8(CAS DataBase Reference)
Trimeprazine tartrate Usage And Synthesis
Chemical Properties
White to Off-White Solid
Uses
Antipruritic. Antibacterial, antimicrobial agent
brand name
Temaril (Allergan).
General Description
Trimeprazine tartrate, (±)10-[3-(dimethylamino)-2-methylpropyl] phenothiazine tartrate(Temaril), occurs as a white to off-white crystalline powderthat is freely soluble in water and soluble in alcohol. Its antihistaminicaction is reported to be from 1.5 to 5 times thatof promethazine. Clinical studies have shown it has a pronouncedantipruritic action that may be unrelated to itshistamine-antagonizing properties.
in vivo
Alimemazine hemitartrate (10 mg/kg, intraperitoneal injection, once a day for 3 weeks) promotes mouse β-cell growth[2].
Alimemazine hemitartrate (10 mg/kg, intraperitoneal injection, once a day for 22 days) synergistically reduces the progression of diabetes in NOD mice[2].
Alimemazine hemitartrate (10 mg/kg, intraperitoneal injection, once a day for 7 days) promotes the proliferation and survival of β-cells in normal mice, but has little effect on β-cell defects caused by IRS2 deficiency[2].
Alimemazine hemitartrate (10 mg/kg, oral gavage, two doses) does not reduce mouse lung virus titers[3].
| Animal Model: | Pdx1+/– mice[2] |
| Dosage: | 10 mg/kg, once a day for 3 weeks |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Increased HOMA 2%B and normalized glucose tolerance in mice. |
| Animal Model: | Irs2-/–mice[2] |
| Dosage: | 10 mg/kg, once a day for seven days |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Did not restore the function of β cells, but promoted β cell growth and increased the area of β cells in normal mice. Increased the concentration of IRS2 protein, had no effect on glucose tolerance in mice, and did not change the insulin sensitivity of mice. |
| Animal Model: | SARS-CoV-2 multiplication in mice[3] |
| Dosage: | 10mg/kg, at 1 h prior to and 24 h after virus inoculation |
| Administration: | i.g. |
| Result: | Did not reduce lung virus titers. |
IC 50
GPCR
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Trimeprazine tartrate (4330-99-8)Related Product Information
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- Trimeprazine
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- D-Tartaric acid
- D(-)-Tartaric acid
- Triallylamine
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- Zolpidem tartrate
- Butanedioic acid,2,3-dihydroxy- (2R,3R)-, ammonium salt (1:)
- Promazine
- Phenothiazine
- Sodium tartrate