RS 102895
RS 102895 Basic information
- Product Name:
- RS 102895
- Synonyms:
-
- 1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride
- 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride
- RS 102895 HYDROCHLORIDE
- 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one
- 1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE
- Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-
- 1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
- CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895
- CAS:
- 300815-41-2
- MF:
- C21H21F3N2O2
- MW:
- 390.4
- Product Categories:
-
- RS 102895 CCR2-selective chemokine receptor antagonist.
- Cytokine signaling
- Mol File:
- 300815-41-2.mol
RS 102895 Chemical Properties
- Boiling point:
- 446.1±45.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Desiccate at RT
- solubility
- DMSO: 18 mg/mL, clear, colorless
- form
- powder
- pka
- 13.46±0.20(Predicted)
- color
- white
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
RS 102895 Usage And Synthesis
Uses
RS 102895 is a CCR2-selective chemokine receptor inhibitor.
Biological Activity
CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors.
in vivo
RS102895 (3 g/L) causes progressive decrease in pain threshold in rats with bone cancer pain (BCP) at day 3-9 after surgery via intrathecal injection, but the pain threshold increases after 12 days. RS102895 also potently reverses the pattern of NR2B, nNOS, and SIGIRR expression in spinal cord[3].
IC 50
CCR2: 360 nM (IC50); CCR1: 17800 nM (IC50); Human α1a receptor: 130 nM (IC50); Human α1d receptor: 320 nM (IC50); 5HT-1a receptor: 470 nM (IC50)
RS 102895Supplier
- Tel
- sales@boylechem.com
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 0330-2528181
- sales@vdmbio.com
- Tel
- 021-58955995
- sales@medchemexpress.cn
- Tel
- 0755-0755-66853366 13670046396
- sales@chem-strong.com
RS 102895(300815-41-2)Related Product Information
- 2,3-Dichloro-5-(trifluoromethyl)pyridine
- 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride
- Inter-trifluoromethyl iodobenzene
- 4-(2-AMINOPHENYL)-1-PHENETHYLPIPERIDINE
- 4-(O-AMINO-PHENYL) PIPERIDINE HYDROCHLORIDE
- RS 102895
- 1-Phenethyl-4-phenyl-4-piperidinol
- SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE