RS 102895 Chemical Properties

Boiling point:

446.1±45.0 °C(Predicted)

Density 

1.33±0.1 g/cm3 (20 ºC 760 Torr)

storage temp. 

Desiccate at RT

solubility 

DMSO: 18 mg/mL, clear, colorless

form 

powder

pka

13.46±0.20(Predicted)

color 

white

InChI

1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H

InChIKey

KRRISOFSWVKYBF-UHFFFAOYSA-N

SMILES

Cl.FC(F)(F)c1ccc(CCN2CCC3(CC2)OC(=O)Nc4ccccc34)cc1

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

Storage Class

11 - Combustible Solids

RS 102895 Usage And Synthesis

Uses

RS 102895 is a CCR2-selective chemokine receptor inhibitor.

Biological Activity

CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors.

in vivo

IC 50

CCR2: 360 nM (IC₅₀); CCR1: 17800 nM (IC₅₀); Human α_1a receptor: 130 nM (IC₅₀); Human α_1d receptor: 320 nM (IC₅₀); 5HT-1a receptor: 470 nM (IC₅₀)

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