RS 102895
RS 102895 Basic information
- Product Name:
- RS 102895
- Synonyms:
-
- 1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride
- 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride
- RS 102895 HYDROCHLORIDE
- 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one
- 1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE
- Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-
- 1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
- CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895
- CAS:
- 300815-41-2
- MF:
- C21H21F3N2O2
- MW:
- 390.4
- Product Categories:
-
- RS 102895 CCR2-selective chemokine receptor antagonist.
- Cytokine signaling
- Mol File:
- 300815-41-2.mol
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RS 102895 Chemical Properties
- Boiling point:
- 446.1±45.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Desiccate at RT
- solubility
- DMSO: 18 mg/mL, clear, colorless
- form
- powder
- pka
- 13.46±0.20(Predicted)
- color
- white
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Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
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RS 102895 Usage And Synthesis
Uses
RS 102895 is a CCR2-selective chemokine receptor inhibitor.
Biological Activity
CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors.
RS 102895Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
VDM Biochemicals
- Tel
- 0330-2528181
- sales@vdmbio.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
ChemStrong Scientific Co.,Ltd
- Tel
- 0755-66853366 13670046396
- sales@chem-strong.com
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RS 102895(300815-41-2)Related Product Information
- 2,3-Dichloro-5-(trifluoromethyl)pyridine
- 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride
- Inter-trifluoromethyl iodobenzene
- 4-(2-AMINOPHENYL)-1-PHENETHYLPIPERIDINE
- 4-(O-AMINO-PHENYL) PIPERIDINE HYDROCHLORIDE
- RS 102895
- 1-Phenethyl-4-phenyl-4-piperidinol
- SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE