Alectinib Impurity Chemical Properties

Boiling point:

696.8±55.0 °C(Predicted)

Density 

1.31±0.1 g/cm3(Predicted)

solubility 

Dichloromethane; Methanol

pka

13.70±0.40(Predicted)

form 

Solid

color 

Pale Yellow

Alectinib Impurity Usage And Synthesis

Uses

9-Ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-8-(4-oxo-1-piperidinyl)-5H-benzo[b]carbazole-3-carbonitrile is an intermediate in synthesizing Alectinib M4 metabolite (A521150). It is the major active metabolite of Alectinib. Alectinib is an anaplastic lymphoma kinase (ALK) inhibitor and is used to treat non-?small-?cell lung cancer by blocking the activity of anaplastic lymphoma kinase (ALK).