Danshensu Sodium Salt
Danshensu Sodium Salt Basic information
- Product Name:
- Danshensu Sodium Salt
- Synonyms:
-
- Danshensu Sodium Salt
- Sodium Dahshensu
- (R)-(+)-3-(3,4-Dihydroxyphenyl)lactic acid
- (R)-α,3,4-Trihydroxy-benzenepropanoic acid sodium salt
- 3-(3′,4′-Dihydroxyphenyl)-(2R)-lactic acid sodium salt
- DS 182
- Salianic acid A
- (R)-Sodium Danshensu
- CAS:
- 81075-52-7
- MF:
- C9H11NaO5
- MW:
- 222.17
- Mol File:
- 81075-52-7.mol
Danshensu Sodium Salt Chemical Properties
- Melting point:
- >230°C (dec.)
- storage temp.
- 2-8°C
- solubility
- H2O: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
- optical activity
- [α]/D +30 to +40°, c = 1 in H2O
- Water Solubility
- H2O: 20mg/mL, clear
- Stability:
- Hygroscopic
Danshensu Sodium Salt Usage And Synthesis
Uses
Sodium Danshensu is exhibits protective effects on the excitotoxicity of monosodium glutamate in the late stage of pregnancy on developing mouse fetal brain.
Biochem/physiol Actions
Danshensu is an active component of Salvia miltiorrhiza (Danshen) that suppresses the formation of reactive oxygen species, inhibits platelet adhesion and aggregation, and protects myocardium against ischemia. Danshensu is cardioprotective, which protects myocardium from the reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation.
in vivo
Danshensu (Dan shen suan A; 25, 50, 100?mg/kg; oral administration daily for 7 continuous days or i.v. once) sodium before SARS-CoV-2 S infection dose-dependently alleviates the pathological alterations in mice infected with SARS-CoV-2 S[1].
| Animal Model: | Adult BALB/c mice (male, 6-8 weeks, 20±2?g)[1] |
| Dosage: | 25, 50, 100?mg/kg |
| Administration: | Oral administration (daily for 7 continuous days) or i.v. (once) |
| Result: | Could prevent SARS-CoV-2 S protein-induced acute lung inflammation. Ameliorated inflammatory cytokines in serum and lung tissue. |
Danshensu Sodium SaltSupplier
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Tel
- 857-239-0968
- service1@targetmol.com
- Tel
- 19150123681
- Hu.xinyue@purechemland.com
- Tel
- 021-67187366 19901745723
- info@bwtlab.com
- Tel
- 029-81136151 17392212881
- 1095@dideu.com