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Danshensu

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Danshensu Basic information

Product Name:
Danshensu
Synonyms:
  • SALVIANIC ACID A
  • SALVIANIC ACID A SODIUM SALT
  • (r)-a,3,4-trihydroxybenzenepropanoic acid
  • Danshensu
  • dan shen suan a
  • (R)-2-Hydroxy-3-(3,4-dihydroxyphenyl)propanoic acid
  • (R)-2-Hydroxy-3-(3,4-dihydroxyphenyl)propionic acid
  • 3-(3,4-Dihydroxyphenyl)-D-lactic acid
CAS:
76822-21-4
MF:
C9H10O5
MW:
198.17
Product Categories:
  • Plant extracts
  • 76822-21-4
Mol File:
76822-21-4.mol
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Danshensu Chemical Properties

Melting point:
>210°C (dec.)
Boiling point:
481.5±40.0 °C(Predicted)
Density 
1.546
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Water (Slightly)
form 
Solid
pka
3.82±0.10(Predicted)
color 
Light Beige
InChI
InChI=1/C9H10O5/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14/h1-3,8,10-12H,4H2,(H,13,14)/t8-/s3
InChIKey
PAFLSMZLRSPALU-SBYBRXNCNA-N
SMILES
C(=O)(O)[C@H](O)CC1=CC=C(O)C(O)=C1 |&1:3,r|
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Danshensu Usage And Synthesis

Chemical Properties

White crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Salvia miltiorrhiza.

Uses

Danshensu increases production of collagenin Detroit 551 cells and attenuates the α-MSH-stimulated melanin production of B16 cells. Danshensu may be used as active ingredients in would healing, cosmetic treatments or treating hyperpigmentation.

Definition

ChEBI: (2R)-3-(3,4-dihydroxyphenyl)lactic acid is a (2R)-2-hydroxy monocarboxylic acid that is (R)-lactic acid substituted at position 3 by a 3,4-dihydroxyphenyl group. It is a (2R)-2-hydroxy monocarboxylic acid and a 3-(3,4-dihydroxyphenyl)lactic acid. It is a conjugate acid of a (2R)-3-(3,4-dihydroxyphenyl)lactate.

in vivo

Danshensu (Dan shen suan A; 25, 50, 100?mg/kg; oral administration daily for 7 continuous days or i.v. once) before SARS-CoV-2 S infection dose-dependently alleviates the pathological alterations in mice infected with SARS-CoV-2 S[1].

Animal Model:Adult BALB/c mice (male, 6-8 weeks, 20±2?g)[1]
Dosage:25, 50, 100?mg/kg
Administration:Oral administration (daily for 7 continuous days) or i.v. (once)
Result:Could prevent SARS-CoV-2 S protein-induced acute lung inflammation.
Ameliorated inflammatory cytokines in serum and lung tissue.

DanshensuSupplier

Shanghai JONLN Reagent Co., Ltd. Gold
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+86-029-88452005 +86-18809298057
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J & K SCIENTIFIC LTD.
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future industrial shanghai co., ltd
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400-0066400 13621662912
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Beijing Ouhe Technology Co., Ltd
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010-010-82967028 13522913783
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2355560935@qq.com
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