N-(3-methoxyphenyl)-2-methyl-1-propionylindoline-5-sulfonamide Chemical Properties

Boiling point:

611.1±65.0 °C(Predicted)

Density 

1.289±0.06 g/cm3(Predicted)

pka

8.56±0.40(Predicted)

N-(3-methoxyphenyl)-2-methyl-1-propionylindoline-5-sulfonamide Usage And Synthesis

Description

VU625 is a potent and selective inhibitor of aedes aegypti inward rectifier potassium channels.

Uses

VU625 is an inhibitor for potassium channel, that selectively inhibits mosquito Aedes aegypti inward rectifier potassium channel 1 (AeKir), with IC50 of 96.8 nM in HEK293 cell. VU625 can be used in development of insecticide[1].

References

[1] Raphemot R, et al., Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels. PLoS One. 2014 Nov 6;9(11):e110772. DOI:10.1371/journal.pone.0110772

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