N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt
N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt Basic information
- Product Name:
- N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt
- Synonyms:
-
- N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt
- E3 ligase Ligand-Linker Conjugates 16
- E3 ligase Ligand-Linker Conjugates 19 (TFA)
- Cereblon Ligand-Linker Conjugates 6 TFA
- N-(4-aminobutyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide
- Pomalidomide Related Compound 4 Triflate
- N-(4-Aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide 2,2,2-trifluoroacetate
- Thalidomide O amido C4 NH2 TFA,inhibit,ThalidomideOamidoC4NH2 TFA,E3 ligase Ligand-Linker Conjugates 19,Thalidomide-O-amido-C-4-NH2 TFA,E3 Ligase Ligand-Linker Conjugates,Cereblon Ligand-Linker Conjugates 6,Inhibitor
- CAS:
- 1799711-25-3
- MF:
- C21H23F3N4O8
- MW:
- 516.43
- Mol File:
- 1799711-25-3.mol
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N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt Chemical Properties
- storage temp.
- 2-8°C, stored under nitrogen
- form
- Solid
- color
- White to off-white
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N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt Usage And Synthesis
Uses
Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
IC 50
Cereblon
References
[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2017 Mar 24. DOI:10.1021/acs.jmedchem.6b01816
[2] James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.
N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA saltSupplier
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N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt(1799711-25-3)Related Product Information
- E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate
- E3 ligase Ligand-Linker Conjugates 5 Free Base
- Thalidomide-O-amido-C3-NH2 (TFA)
- N-(prop-2-yn-1-yl)-4-(pyren-1-yl)butanamide
- N-(6-aminocaproyl)azadibenzocyclooctyne
- N-(3-azidopropyl)-4-(pyren-1-yl)butanamide
- N-(3-methoxyphenyl)-2-methyl-1-propionylindoline-5-sulfonamide
- N-(3-methoxyphenyl)-N-((2-methyl-1-propionylindolin-5-yl)sulfonyl)propionamide
- N-(4-(1H-imidazol-1-yl)phenyl)-4-(1H-imidazol-1-yl)-N-phenylaniline
- E3 Ligase Ligand-Linker Conjugates 19
- E3 Ligase Ligand-Linker Conjugates 1
- E3 ligase Ligand-Linker Conjugates 17
- E3 ligase Ligand-Linker Conjugates 14
- 4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione