E3 ligase Ligand-Linker Conjugates 5 Free Base Chemical Properties

Boiling point:

879.2±65.0 °C(Predicted)

Density 

1.238±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

pka

13.54±0.46(Predicted)

form 

Solid

color 

Light yellow to yellow

E3 ligase Ligand-Linker Conjugates 5 Free Base Usage And Synthesis

Description

(S, R, S)-AHPC-PEG3-amine hydrochloride salt is comprised of VHL Ligand coupled to an amine via a PEG3 linker. The 1 VHL Ligand 1 is a synthetic compound used in PROTAC research based on E3 ligase ligand. NH2 group is reactive with carboxylic acids in the presence of coupling reagent such as EDC , or directly with NHS esters, to form a stable amide bond.

Uses

(S,R,S)-AHPC-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

IC 50

VHL

References

[1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Me DOI:10.1021/acs.jmedchem.6b01912

E3 ligase Ligand-Linker Conjugates 5 Free Base(2010159-56-3)Related Product Information

• N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt
• E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate
• E3 ligase Ligand-Linker Conjugates 17
• E3 ligase Ligand-Linker Conjugates 14
• Thalidomide-O-amido-C3-NH2 (TFA)
• 4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione