E3 ligase Ligand-Linker Conjugates 5 Free Base CAS#: 2010159-56-3

E3 ligase Ligand-Linker Conjugates 5 Free Base Basic information

Product Name:

E3 ligase Ligand-Linker Conjugates 5 Free Base

Synonyms:

E3 ligase Ligand-Linker Conjugates 5 Free Base
(S,R,S)-AHPC-PEG3-NH2
VH032-PEG3-NH2
VHL Ligand-Linker Conjugates 1
PROTACs Related Compound 7
L-Prolinamide, N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
(S,R,S)-AHPC-PEG3-NH2 （E3 ligase Ligand-Linker Conjugates 5）
(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CAS:

2010159-56-3

MF:

C30H45N5O7S

MW:

619.77

Mol File:

2010159-56-3.mol

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E3 ligase Ligand-Linker Conjugates 5 Free Base Chemical Properties

Boiling point:: 879.2±65.0 °C(Predicted)
Density: 1.238±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
pka: 13.54±0.46(Predicted)

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E3 ligase Ligand-Linker Conjugates 5 Free Base Usage And Synthesis

Description

(S, R, S)-AHPC-PEG3-amine hydrochloride salt is comprised of VHL Ligand coupled to an amine via a PEG3 linker. The 1 VHL Ligand 1 is a synthetic compound used in PROTAC research based on E3 ligase ligand. NH2 group is reactive with carboxylic acids in the presence of coupling reagent such as EDC , or directly with NHS esters, to form a stable amide bond.

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