E3 ligase Ligand-Linker Conjugates 5 Free Base

Product Name: E3 ligase Ligand-Linker Conjugates 5 Free Base
CAS No.: 2010159-56-3
Chemical Name: E3 ligase Ligand-Linker Conjugates 5 Free Base
Synonyms: VH032-PEG3-NH2;(S,R,S)-AHPC-PEG3-NH2;PROTACs Related Compound 7;VHL Ligand-Linker Conjugates 1;(S, R, S)-AHPC-PEG3-amine hydrochloride salt;E3 ligase Ligand-Linker Conjugates 5 Free Base;(S,R,S)-AHPC-PEG3-NH2 （E3 ligase Ligand-Linker Conjugates 5）;L-Prolinamide, N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(S)-14-Amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl]-4-hydroxy-N-[4-(4-methyl-5-thiazolyl)benzyl]pyrrolidine-2-carboxamide
CBNumber: CB14797051
Molecular Formula: C30H45N5O7S
Formula Weight: 619.77
MOL File: 2010159-56-3.mol

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E3 ligase Ligand-Linker Conjugates 5 Free Base Property

Boiling point:: 879.2±65.0 °C(Predicted)
Density: 1.238±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
pka: 13.54±0.46(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals

Product number: 027598
Product name: (S,R,S)-AHPC-PEG3-NH2（E3ligaseLigand-LinkerConjugates5）
Packaging: 001
Price: $500
Updated: 2021/12/16

DC Chemicals

Product number: 027598
Product name: (S,R,S)-AHPC-PEG3-NH2（E3ligaseLigand-LinkerConjugates5）
Packaging: 003
Price: $1700
Updated: 2021/12/16

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E3 ligase Ligand-Linker Conjugates 5 Free Base Chemical Properties,Usage,Production

Description

(S, R, S)-AHPC-PEG3-amine hydrochloride salt is comprised of VHL Ligand coupled to an amine via a PEG3 linker. The 1 VHL Ligand 1 is a synthetic compound used in PROTAC research based on E3 ligase ligand. NH2 group is reactive with carboxylic acids in the presence of coupling reagent such as EDC , or directly with NHS esters, to form a stable amide bond.

Uses

(S,R,S)-AHPC-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

IC 50

VHL

References

[1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Me DOI:10.1021/acs.jmedchem.6b01912

E3 ligase Ligand-Linker Conjugates 5 Free Base Preparation Products And Raw materials

Raw materials

Preparation Products

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Shanghai Xinketai Biotechnology Co., Ltd

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View Lastest Price from E3 ligase Ligand-Linker Conjugates 5 Free Base manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (S,R,S)-AHPC-PEG3-NH2 2010159-56-3
Price: US $0.00/mg
Min. Order: 100mg
Purity: >98.00%
Supply Ability: 100mg
Release date: 2024-04-01

2010159-56-3, E3 ligase Ligand-Linker Conjugates 5 Free BaseRelated Search:

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E3 ligase Ligand-Linker Conjugates 5 Free Base

(S,R,S)-AHPC-PEG3-NH2

VH032-PEG3-NH2

VHL Ligand-Linker Conjugates 1

PROTACs Related Compound 7

L-Prolinamide, N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

(S,R,S)-AHPC-PEG3-NH2 （E3 ligase Ligand-Linker Conjugates 5）

(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

(S, R, S)-AHPC-PEG3-amine hydrochloride salt

(2S,4R)-1-[(S)-14-Amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl]-4-hydroxy-N-[4-(4-methyl-5-thiazolyl)benzyl]pyrrolidine-2-carboxamide

(2S,4R)-1-[(2S)-2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

2010159-56-3