N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt

Product Name: N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt
CAS No.: 1799711-25-3
Chemical Name: N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt
Synonyms: E3 ligase Ligand-Linker Conjugates 16;Cereblon Ligand-Linker Conjugates 6 TFA;Pomalidomide Related Compound 4 Triflate;E3 ligase Ligand-Linker Conjugates 19 (TFA);Thalidomide-O-amido-C4-NH2 TFA, 10 mM in DMSO;N-(4-aminobutyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide;N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt;N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide trifluoroacetate;N-(4-Aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide 2,2,2-trifluoroacetate;Thalidomide O amido C4 NH2 TFA,inhibit,ThalidomideOamidoC4NH2 TFA,E3 ligase Ligand-Linker Conjugates 19,Thalidomide-O-amido-C-4-NH2 TFA,E3 Ligase Ligand-Linker Conjugates,Cereblon Ligand-Linker Conjugates 6,Inhibitor
CBNumber: CB63959899
Molecular Formula: C21H23F3N4O8
Formula Weight: 516.43
MOL File: 1799711-25-3.mol

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N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt Property

storage temp.: 2-8°C, stored under nitrogen
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb573254
Product name: E3 ligase Ligand-Linker Conjugates 16
Purity: >98%
Packaging: 500mg
Price: $1504.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573254
Product name: E3 ligase Ligand-Linker Conjugates 16
Purity: >98%
Packaging: 1g
Price: $2691.1
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573254
Product name: E3 ligase Ligand-Linker Conjugates 16
Purity: >98%
Packaging: 2g
Price: $3876
Updated: 2021/12/16

DC Chemicals

Product number: DC12674
Product name: E3ligaseLigand-LinkerConjugates16
Purity: >98%
Packaging: 2g
Price: $2600
Updated: 2021/12/16

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N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt Chemical Properties,Usage,Production

Uses

Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

IC 50

Cereblon

References

[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2017 Mar 24. DOI:10.1021/acs.jmedchem.6b01816
[2] James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.

N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt Suppliers

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1799711-25-3, N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA saltRelated Search:

E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate E3 ligase Ligand-Linker Conjugates 5 Free Base Thalidomide-O-amido-C3-NH2 (TFA) N-(prop-2-yn-1-yl)-4-(pyren-1-yl)butanamide N-(6-aminocaproyl)azadibenzocyclooctyne N-(3-azidopropyl)-4-(pyren-1-yl)butanamide N-(3-methoxyphenyl)-2-methyl-1-propionylindoline-5-sulfonamide N-(3-methoxyphenyl)-N-((2-methyl-1-propionylindolin-5-yl)sulfonyl)propionamide N-(4-(1H-imidazol-1-yl)phenyl)-4-(1H-imidazol-1-yl)-N-phenylaniline E3 Ligase Ligand-Linker Conjugates 19 E3 Ligase Ligand-Linker Conjugates 1 E3 ligase Ligand-Linker Conjugates 17 E3 ligase Ligand-Linker Conjugates 14 4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt

E3 ligase Ligand-Linker Conjugates 16

E3 ligase Ligand-Linker Conjugates 19 (TFA)

Cereblon Ligand-Linker Conjugates 6 TFA

N-(4-aminobutyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide

Pomalidomide Related Compound 4 Triflate

N-(4-Aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide 2,2,2-trifluoroacetate

Thalidomide O amido C4 NH2 TFA,inhibit,ThalidomideOamidoC4NH2 TFA,E3 ligase Ligand-Linker Conjugates 19,Thalidomide-O-amido-C-4-NH2 TFA,E3 Ligase Ligand-Linker Conjugates,Cereblon Ligand-Linker Conjugates 6,Inhibitor

N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide trifluoroacetate

Thalidomide-O-amido-C4-NH2 TFA, 10 mM in DMSO

1799711-25-3

C21H23F3N4O8