E3 Ligase Ligand-Linker Conjugates 19

Product Name: E3 Ligase Ligand-Linker Conjugates 19
CAS No.: 1799711-24-2
Chemical Name: E3 Ligase Ligand-Linker Conjugates 19
Synonyms: Pomadomide impurity 27;Thalidomide-O-amido-C4-NH2;E3 Ligand-Linker Conjugate 3;Cereblon Ligand-Linker Conjugates 6;E3 Ligase Ligand-Linker Conjugates 19;E3 Ligand-Linker Conjugate 3(E3 Ligase Ligand-Linker Conjugates 19);N-(4-Aminobutyl)-2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]oxy]acetamide;N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide;N-(4-Aminobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide;N-(4-aminobutyl)-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide
CBNumber: CB83386468
Molecular Formula: C19H22N4O6
Formula Weight: 402.4
MOL File: 1799711-24-2.mol

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E3 Ligase Ligand-Linker Conjugates 19 Property

Boiling point:: 757.5±60.0 °C(Predicted)
Density: 1.397±0.06 g/cm3(Predicted)
solubility: DMF: insol; DMSO: insol; Ethanol: insol; PBS (pH 7.2): 3 mg/ml
form: A solid
pka: 10.68±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC22869
Product name: E3Ligand-LinkerConjugate3
Purity: >98%
Packaging: 250mg
Price: $1100
Updated: 2021/12/16

A1 Biochem Labs

Product number: 6589660
Product name: N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
Purity: 95%
Packaging: 500mg
Price: $1400
Updated: 2021/12/16

DC Chemicals

Product number: DC22869
Product name: E3Ligand-LinkerConjugate3
Purity: >98%
Packaging: 1g
Price: $2000
Updated: 2021/12/16

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E3 Ligase Ligand-Linker Conjugates 19 Chemical Properties,Usage,Production

Description

Thalidomide-O-acetamido-C4-amine HCl salt is comprised of a Thalidomide based cereblon ligand and a ligand-linker conjugate. This E3 ligase ligand-linker conjugate is used in PROTAC technology.

Uses

Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

IC 50

Cereblon

References

[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression.J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
[2] James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.

E3 Ligase Ligand-Linker Conjugates 19 Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 Ligase Ligand-Linker Conjugates 19 Suppliers

China 32 United States 3 Global 35

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1799711-24-2, E3 Ligase Ligand-Linker Conjugates 19Related Search:

E3 Ligase Ligand-Linker Conjugates 22 E3 ligase Ligand-Linker Conjugates 11 1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- Cereblon Ligand 1 E3 Ligase Ligand-Linker Conjugates 21 Thalidomide-O-PEG4-Propargyl Thalidomide-linker 10 Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride Thalidomide-O-amido-C8-NH2 hydrochloride Thalidomide-O-PEG4-Boc tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate Thalidomide-linker 13 E3 Ligase Ligand-Linker Conjugates 20 E3 ligase Ligand-Linker Conjugates 17 E3 Ligase Ligand-Linker Conjugates 1 N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt

E3 Ligase Ligand-Linker Conjugates 19

E3 Ligand-Linker Conjugate 3

Cereblon Ligand-Linker Conjugates 6

Thalidomide-O-amido-C4-NH2

Acetamide, N-(4-aminobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-

N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

E3 Ligand-Linker Conjugate 3(E3 Ligase Ligand-Linker Conjugates 19)

N-(4-Aminobutyl)-2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]oxy]acetamide

N-(4-aminobutyl)-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide

Pomadomide impurity 27

N-(4-Aminobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

1799711-24-2