E3 Ligase Ligand-Linker Conjugates 19

Product Name: E3 Ligase Ligand-Linker Conjugates 19
CAS No.: 1799711-24-2
Chemical Name: E3 Ligase Ligand-Linker Conjugates 19
Synonyms: Pomadomide impurity 27;Thalidomide-O-amido-C4-NH2;E3 Ligand-Linker Conjugate 3;Cereblon Ligand-Linker Conjugates 6;E3 Ligase Ligand-Linker Conjugates 19;E3 Ligand-Linker Conjugate 3(E3 Ligase Ligand-Linker Conjugates 19);N-(4-Aminobutyl)-2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]oxy]acetamide;N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide;N-(4-aminobutyl)-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide;Acetamide, N-(4-aminobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
CBNumber: CB83386468
Molecular Formula: C19H22N4O6
Formula Weight: 402.4
MOL File: 1799711-24-2.mol

More

Less

E3 Ligase Ligand-Linker Conjugates 19 Property

Boiling point:: 757.5±60.0 °C(Predicted)
Density: 1.397±0.06 g/cm3(Predicted)
solubility: DMF: insol; DMSO: insol; Ethanol: insol; PBS (pH 7.2): 3 mg/ml
form: A solid
pka: 10.68±0.40(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

DC Chemicals

Product number: DC22869
Product name: E3Ligand-LinkerConjugate3
Purity: >98%
Packaging: 250mg
Price: $1100
Updated: 2021/12/16

A1 Biochem Labs

Product number: 6589660
Product name: N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
Purity: 95%
Packaging: 500mg
Price: $1400
Updated: 2021/12/16

DC Chemicals

Product number: DC22869
Product name: E3Ligand-LinkerConjugate3
Purity: >98%
Packaging: 1g
Price: $2000
Updated: 2021/12/16

More

Less

E3 Ligase Ligand-Linker Conjugates 19 Chemical Properties,Usage,Production

Description

Thalidomide-O-acetamido-C4-amine HCl salt is comprised of a Thalidomide based cereblon ligand and a ligand-linker conjugate. This E3 ligase ligand-linker conjugate is used in PROTAC technology.

Uses

Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

IC 50

Cereblon

References

[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression.J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
[2] James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.

E3 Ligase Ligand-Linker Conjugates 19 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

E3 Ligase Ligand-Linker Conjugates 19 Suppliers

China 30 United States 3 Global 33

BioPharmaMatrix,Inc.

Tel: 0510-86010668
Fax: 0510-86010668
Email: sales@biopharmamatrix.com
Country: China
ProdList: 4739
Advantage: 55

SuZhou Medinoah Co.,LTD.

Tel: 0512-69561983 13914027025
Fax: 0512-69561982
Email: zhang_q@medinoah.com
Country: China
ProdList: 3811
Advantage: 58

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
Country: China
ProdList: 1615
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

Shanghai Minhan Pharmaceutical Technology Co., Ltd.

Tel: 17612188245
Fax: QQ 2816925681
Email: 2816925681@qq.com
Country: China
ProdList: 2989
Advantage: 58

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80514535 19917294565
Email: ET-market@chemextension.com
Country: China
ProdList: 4672
Advantage: 58

Molcoo Chemicals Inc.

Tel: 18576690171
Email: 3001025734@qq.com
Country: China
ProdList: 8880
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62220
Advantage: 58

Shenzhen Roark Pharma-Tec Co., Ltd.

Tel: 13128912434
Email: 2880126944@qq.com
Country: China
ProdList: 3100
Advantage: 58

1799711-24-2, E3 Ligase Ligand-Linker Conjugates 19Related Search:

E3 Ligase Ligand-Linker Conjugates 22 E3 ligase Ligand-Linker Conjugates 11 1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- Cereblon Ligand 1 E3 Ligase Ligand-Linker Conjugates 21 Thalidomide-O-PEG4-Propargyl Thalidomide-linker 10 Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride Thalidomide-O-amido-C8-NH2 hydrochloride Thalidomide-O-PEG4-Boc tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate Thalidomide-linker 13 E3 Ligase Ligand-Linker Conjugates 20 E3 ligase Ligand-Linker Conjugates 17 E3 Ligase Ligand-Linker Conjugates 1 N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt

E3 Ligase Ligand-Linker Conjugates 19

E3 Ligand-Linker Conjugate 3

Cereblon Ligand-Linker Conjugates 6

Thalidomide-O-amido-C4-NH2

Acetamide, N-(4-aminobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-

N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

E3 Ligand-Linker Conjugate 3(E3 Ligase Ligand-Linker Conjugates 19)

N-(4-Aminobutyl)-2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]oxy]acetamide

N-(4-aminobutyl)-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide

Pomadomide impurity 27

1799711-24-2