Thalidomide-O-amido-C8-NH2 hydrochloride

Product Name: Thalidomide-O-amido-C8-NH2 hydrochloride
CAS No.: 2415263-07-7
Chemical Name: Thalidomide-O-amido-C8-NH2 hydrochloride
Synonyms: Thalidomide-O-amido-C8-NH2 hydrochloride;Thalidomide 4'-oxyacetamide-alkylC8-amine;N-(8-aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide hydrochloride
CBNumber: CB49023929
Molecular Formula: C23H31ClN4O6
Formula Weight: 494.97
MOL File: 2415263-07-7.mol

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Hazard and Precautionary Statements (GHS)

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Thalidomide-O-amido-C8-NH2 hydrochloride Chemical Properties,Usage,Production

Uses

Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

Biological Activity

Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1]. Thalidomide-O-amido-C8-NH2 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is bound lo at least one targeting ligand. Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein(s)[1].

IC 50

Cereblon

storage

Desiccate at RT

References

[1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.

Thalidomide-O-amido-C8-NH2 hydrochloride Preparation Products And Raw materials

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Xian confluore Biological Technology Co., Ltd.

Product: Thalidomide-O-amido-C8-NH2 hydrochloride 2415263-07-7
Price: US $0.00/mg
Min. Order: 100mg
Purity: >98.00%
Supply Ability: 100mg
Release date: 2024-04-01

2415263-07-7, Thalidomide-O-amido-C8-NH2 hydrochlorideRelated Search:

Thalidomide-O-amido-PEG4-azide Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride Thalidomide-linker 14 N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide 1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- Cereblon Ligand 1 E3 Ligase Ligand-Linker Conjugates 21 E3 Ligase Ligand-Linker Conjugates 19 Thalidomide-O-PEG4-Propargyl Thalidomide-linker 10 Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride Thalidomide-O-PEG4-Boc tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate Thalidomide-linker 13 Thalidomide-linker 15 E3 Ligase Ligand-Linker Conjugates 24 (TFA)

Thalidomide-O-amido-C8-NH2 hydrochloride

N-(8-aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide hydrochloride

Thalidomide 4'-oxyacetamide-alkylC8-amine

2415263-07-7