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Thalidomide-O-amido-C8-NH2 hydrochloride

Product Name
Thalidomide-O-amido-C8-NH2 hydrochloride
CAS No.
2415263-07-7
Chemical Name
Thalidomide-O-amido-C8-NH2 hydrochloride
Synonyms
Thalidomide-O-amido-C8-NH2 hydrochloride;N-(8-aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide hydrochloride
CBNumber
CB49023929
Molecular Formula
C23H31ClN4O6
Formula Weight
494.97
MOL File
2415263-07-7.mol
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Hazard and Precautionary Statements (GHS)

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Thalidomide-O-amido-C8-NH2 hydrochloride Chemical Properties,Usage,Production

Biological Activity

Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1]. Thalidomide-O-amido-C8-NH2 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is bound lo at least one targeting ligand. Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein(s)[1].

storage

Desiccate at RT

References

[1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.

Thalidomide-O-amido-C8-NH2 hydrochloride Preparation Products And Raw materials

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Preparation Products

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Xi'an Confluore Biological Technology Co., Ltd.
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Xian confluore Biological Technology Co., Ltd.
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Aladdin Scientific
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View Lastest Price from Thalidomide-O-amido-C8-NH2 hydrochloride manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Thalidomide-O-amido-C8-NH2 hydrochloride 2415263-07-7
Price
US $0.00/mg
Min. Order
100mg
Purity
>98.00%
Supply Ability
100mg
Release date
2024-04-01