Thalidomide-O-amido-PEG4-azide

Product Name: Thalidomide-O-amido-PEG4-azide
CAS No.: 2411681-89-3
Chemical Name: Thalidomide-O-amido-PEG4-azide
Synonyms: Thalidomide-O-amido-PEG4-azide;N-(14-Azido-3,6,9,12-tetraoxatetradecyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide;Acetamide, N-(14-azido-3,6,9,12-tetraoxatetradec-1-yl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
CBNumber: CB38054837
Molecular Formula: C25H32N6O10
Formula Weight: 576.56
MOL File: 2411681-89-3.mol

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Thalidomide-O-amido-PEG4-azide Property

storage temp.: -20°C, sealed storage, away from moisture
form: Solid
color: White to off-white

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24454
Product name: Thalidomide-O-amido-PEG4-azide
Purity: 98%
Packaging: 100mg
Price: $540
Updated: 2021/12/16

BroadPharm

Product number: BP-24454
Product name: Thalidomide-O-amido-PEG4-azide
Purity: 98%
Packaging: 250mg
Price: $950
Updated: 2021/12/16

BroadPharm

Product number: BP-24454
Product name: Thalidomide-O-amido-PEG4-azide
Purity: 98%
Packaging: 500mg
Price: $1850
Updated: 2021/12/16

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Thalidomide-O-amido-PEG4-azide Chemical Properties,Usage,Production

Description

Thalidomide-O-amido-PEG4-azide is a PROTAC linker that is reactive with alkyne or DBCO, BCN attached molecule via click chemistry, PEG space increase compound solubility.

Uses

Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Thalidomide-O-amido-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Cereblon

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Thalidomide-O-amido-PEG4-azide Preparation Products And Raw materials

Raw materials

Preparation Products

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Thalidomide-O-amido-PEG4-azide Suppliers

China 20 United States 3 Global 23

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
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Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
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Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
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Jilin Province Woda Biotechnology Co., Ltd.

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Alfa Chemistry

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TargetMol Chemicals Inc.

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Country: United States
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Shanghai Haohong Pharmaceutical Co., Ltd.

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Country: China
ProdList: 55000
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Beijing Jin Ming Biotechnology Co., Ltd.

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Bide Pharmatech Ltd.

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Shanghai Huici Pharmaceutical Technology Co., LTD

Tel: 133-31922809 19372841038
Email: lixing@pharmahuici.com
Country: China
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View Lastest Price from Thalidomide-O-amido-PEG4-azide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Thalidomide-O-amido-PEG4-azide 2411681-89-3
Price: US $0.00/mg
Min. Order: 250mg
Purity: >98.00%
Supply Ability: 250mg
Release date: 2024-04-01

2411681-89-3, Thalidomide-O-amido-PEG4-azideRelated Search:

Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride Thalidomide-linker 14 Thalidomide-linker 13 N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide E3 Ligase Ligand-Linker Conjugates 20 E3 Ligase Ligand-Linker Conjugates 21 E3 Ligase Ligand-Linker Conjugates 19 Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride Thalidomide-linker 15 Thalidomide-O-amido-C8-NH2 hydrochloride Thalidomide-O-amido-PEG1-(C1-?PEG)2-C2-NH2 N-(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide Trifluoroacetate E3 Ligase Ligand-Linker Conjugates 24 (TFA) Acetamide, N-(5-aminopentyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Thalidomide-O-amido-PEG5-NH2 hydrochloride Thalidomide-O-C10-NH2 hydrochloride 1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)

Thalidomide-O-amido-PEG4-azide

Acetamide, N-(14-azido-3,6,9,12-tetraoxatetradec-1-yl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-

N-(14-Azido-3,6,9,12-tetraoxatetradecyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

2411681-89-3