Thalidomide-O-PEG2-azide

Product Name: Thalidomide-O-PEG2-azide
CAS No.: 2758431-90-0
Chemical Name: Thalidomide-O-PEG2-azide
Synonyms: Thalidomide-O-PEG2-azide;Thalidomide 4'-ether-PEG2-azide;4-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-
CBNumber: CB110965774
Molecular Formula: C19H21N5O7
Formula Weight: 431.41
MOL File: 2758431-90-0.mol

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Hazard and Precautionary Statements (GHS)

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Thalidomide-O-PEG2-azide Chemical Properties,Usage,Production

Uses

Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs[1].

Biological Activity

Thalidomide 4'-ether-PEG2-azide is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a PEG2 linker with azide terminal ready for conjugation to a target protein ligand.

storage

Store at -20°C

References

[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. DOI:10.1038/nature13527

Thalidomide-O-PEG2-azide Preparation Products And Raw materials

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Thalidomide-O-PEG2-azide Suppliers

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Xi'an Confluore Biological Technology Co., Ltd.

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Xian confluore Biological Technology Co., Ltd.

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View Lastest Price from Thalidomide-O-PEG2-azide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Thalidomide-O-PEG2-azide 2758431-90-0
Price: US $0.00/mg
Min. Order: 100mg
Purity: >98.00%
Supply Ability: 100mg
Release date: 2024-04-01

2758431-90-0, Thalidomide-O-PEG2-azideRelated Search:

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Thalidomide-O-PEG2-azide

4-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

1H-Isoindole-1,3(2H)-dione, 4-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-

Thalidomide 4'-ether-PEG2-azide

2758431-90-0