1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
- Product Name
- 1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
- CAS No.
- 2636798-38-2
- Chemical Name
- 1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
- Synonyms
- Thalidomide 4'-ether-alkylC8-amine;Thalidomide-O-C8-NH2 hydrochloride;1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
- CBNumber
- CB210724446
- Molecular Formula
- C21H28ClN3O5
- Formula Weight
- 437.92
- MOL File
- 2636798-38-2.mol
1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Property
- form
- Solid
- color
- Off-white to pink
1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Chemical Properties,Usage,Production
Description
WUN-98382 is a functionalized cereblon ligand for PROTAC? research and development. It incorporates an E3 ligase ligand plus an alkylC8 linker with a terminal amine ready for conjugation to a target protein ligand. WUN-98382 is Part of a range of functionalized tool molecules for PROTAC R&D. This product has no formal name.
Uses
Thalidomide-4-O-C8-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
IC 50
Cereblon
storage
Store at -20°C
References
[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) manufacturers
- Product
- Thalidomide-O-C8-NH2 hydrochloride 2636798-38-2
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >95.00%
- Supply Ability
- 100mg
- Release date
- 2024-04-01