N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

Product Name: N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
CAS No.: 2098488-36-7
Chemical Name: N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
Synonyms: Azido-Thalidomide;Cereblon Ligand-Linker Conjugates 4;E3 ligase Ligand-Linker Conjugates 18;Thalidomide-O-amido-C4-N3, 10 mM in DMSO;Thalidomide 4'-oxyacetamide-alkylC4-azide;E3 Ligand-Linker Conjugate 1?, Thalidomide-O-amido-C4-N3;N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide;N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide;Acetamide, N-(4-azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-;Thalidomide O amido C4 N3,ThalidomideOamidoC4N3,Inhibitor,inhibit,Thalidomide-O-amido-C-4-N3,E3 Ligase Ligand-Linker Conjugates
CBNumber: CB13959900
Molecular Formula: C19H20N6O6
Formula Weight: 428.3987
MOL File: 2098488-36-7.mol

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N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide Property

solubility: DMF: 12 mg/ml; DMSO: 12 mg/ml; DMSO:PBS (pH 7.2)(1:8): 0.11 mg/ml
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26146
Product name: Azido-Thalidomide
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 26146
Product name: Azido-Thalidomide
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 26146
Product name: Azido-Thalidomide
Packaging: 25mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 26146
Product name: Azido-Thalidomide
Packaging: 50mg
Price: $477
Updated: 2024/03/01

AK Scientific

Product number: 2261EL
Product name: E3Ligand-LinkerConjugate1
Packaging: 10mg
Price: $225
Updated: 2021/12/16

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N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide Chemical Properties,Usage,Production

Description

UUN 88367, also known as Azido-Thalidomide is a clickable Thalidomide derivative, used as a building block for cereblon. Azido-Thalidomide targets PROTACs by hijacking cereblon as the E3 ubiquitin ligase component. This product has no formal name at the moment.

Uses

Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Cereblon

storage

Store at -20°C

References

[1] Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491. DOI:10.1021/acs.jmedchem.6b01872

N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide Suppliers

China 39 United Kingdom 1 United States 3 Global 43

Bide Pharmatech Ltd.

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TargetMol Chemicals Inc.

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Shaanxi borno biotechnology co., LTD

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View Lastest Price from N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Thalidomide-O-amido-C4-N3 2098488-36-7
Price: US $0.00/mg
Min. Order: 100mg
Purity: >99.00%
Supply Ability: 100mg
Release date: 2024-04-01

2098488-36-7, N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamideRelated Search:

E3 Ligase Ligand-Linker Conjugates 24 (TFA) N-(4-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzyl)-5-fluoro-2-methoxybenzamide E3 Ligase Ligand-Linker Conjugates 21 E3 Ligase Ligand-Linker Conjugates 19 Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride Thalidomide-linker 15 Thalidomide-O-amido-C8-NH2 hydrochloride Acetamide, N-(5-aminopentyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Thalidomide-O-amido-PEG4-azide Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride Thalidomide-linker 14 Thalidomide-linker 13 E3 Ligase Ligand-Linker Conjugates 20

N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

E3 ligase Ligand-Linker Conjugates 18

Azido-Thalidomide

N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

Cereblon Ligand-Linker Conjugates 4

Thalidomide O amido C4 N3,ThalidomideOamidoC4N3,Inhibitor,inhibit,Thalidomide-O-amido-C-4-N3,E3 Ligase Ligand-Linker Conjugates

Thalidomide 4'-oxyacetamide-alkylC4-azide

Acetamide, N-(4-azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-

E3 Ligand-Linker Conjugate 1?, Thalidomide-O-amido-C4-N3

Thalidomide-O-amido-C4-N3, 10 mM in DMSO

2098488-36-7