E3 Ligase Ligand-Linker Conjugates 1

Product Name: E3 Ligase Ligand-Linker Conjugates 1
CAS No.: 2097938-44-6
Chemical Name: E3 Ligase Ligand-Linker Conjugates 1
Synonyms: Pomalidomide-PEG4-C-COOH;E3 Ligase Ligand-Linker Conjugate 1;Cereblon Ligand -Linker Conjugates 1;E3 Ligase Ligand-Linker Conjugates 1;Pomalidomide-PEG4-C-COOH, 10 mM in DMSO;Cereblon Ligand -Linker Conjugates 1|||E3 Ligase Ligand-Linker Conjugates 1;14-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxatetradecan-1-oic Acid;4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecan-1-oic acid;14-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecan-1-oic acid;2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
CBNumber: CB53356150
Molecular Formula: C23H29N3O10
Formula Weight: 507.49
MOL File: 2097938-44-6.mol

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E3 Ligase Ligand-Linker Conjugates 1 Property

Boiling point:: 769.8±60.0 °C(Predicted)
Density: 1.410±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, stored under nitrogen
form: Oil
pka: 3.39±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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E3 Ligase Ligand-Linker Conjugates 1 Chemical Properties,Usage,Production

Uses

Pomalidomide-PEG4-C-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

IC 50

Cereblon

References

[1] Guangrong Zheng, et al. Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof. WO2017184995A1.

E3 Ligase Ligand-Linker Conjugates 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 Ligase Ligand-Linker Conjugates 1 Suppliers

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2097938-44-6, E3 Ligase Ligand-Linker Conjugates 1Related Search:

Pomalidomide-PEG3-CO2H Pomalidomide-PEG2-N3 Pomalidomide-PEG4-azide Pomalidomide-PEG2-butyl iodide E3 Ligase Ligand-Linker Conjugates 22 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-PEG4-CO2H POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG1-azide Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide E3 Ligase Ligand-Linker Conjugates 19 E3 ligase Ligand-Linker Conjugates 17 N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt

E3 Ligase Ligand-Linker Conjugates 1

E3 Ligase Ligand-Linker Conjugate 1

2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

Pomalidomide-PEG4-C-COOH

Cereblon Ligand -Linker Conjugates 1

Acetic acid, 2-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-

14-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihy dro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetra decanoic acid

4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecan-1-oic acid

14-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecan-1-oic acid

14-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxatetradecan-1-oic Acid

Cereblon Ligand -Linker Conjugates 1|||E3 Ligase Ligand-Linker Conjugates 1

Pomalidomide-PEG4-C-COOH, 10 mM in DMSO

2097938-44-6

C23H29N3O10

peg