ChemicalBook > CAS DataBase List > Pomalidomide-PEG2-butyl iodide
Pomalidomide-PEG2-butyl iodide
- Product Name
- Pomalidomide-PEG2-butyl iodide
- CAS No.
- 1835705-72-0
- Chemical Name
- Pomalidomide-PEG2-butyl iodide
- Synonyms
- Pomalidomide-2-2-6-I;Pomalidomide-PEG2-butyl iodide;N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-2-{2-[(6-iodohexyl)oxy]ethoxy}acetamide;Acetamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-2-[2-[(6-iodohexyl)oxy]ethoxy]-;Crosslinker–E3 Ligase ligand conjugate, Pomalidomide-2-2-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-2-(2-((6-iodohexyl)oxy)ethoxy)acetamide, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
- CBNumber
- CB74919985
- Molecular Formula
- C23H28IN3O7
- Formula Weight
- 585.39
- MOL File
- 1835705-72-0.mol
More
Less
Pomalidomide-PEG2-butyl iodide Property
- Boiling point:
- 757.7±60.0 °C(Predicted)
- Density
- 1.588±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 10.68±0.40(Predicted)
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 904724
- Product name
- Pomalidomide-PEG2-butyl iodide
- Purity
- ≥95%
- Packaging
- 50MG
- Price
- $558
- Updated
- 2023/06/20
More
Less
Pomalidomide-PEG2-butyl iodide Chemical Properties,Usage,Production
Uses
Protein degrader builiding block Pomalidomide-PEG2-butyl Iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Pomalidomide-PEG2-butyl iodide Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Pomalidomide-PEG2-butyl iodide Suppliers
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
- Country
- China
- ProdList
- 4824
- Advantage
- 58
- Tel
- 13504435624
- 1927928688@qq.com
- Country
- China
- ProdList
- 1386
- Advantage
- 58
- Tel
- +86-13759708231
- asherw9@hotmail.com
- Country
- China
- ProdList
- 2350
- Advantage
- 58
- Tel
- 0371-0371-55153829 18003835034
- Fax
- 18003835034（微信）
- 2853979819@qq.com
- Country
- China
- ProdList
- 9717
- Advantage
- 58
- Tel
- 2122619822
- czbjpharma@126.com
- Country
- China
- ProdList
- 18478
- Advantage
- 58
- Tel
- 13417589054 13417589054
- trendseenbio@gmail.com
- Country
- China
- ProdList
- 9470
- Advantage
- 58
- Tel
- 0571-8512-5372
- sales@bingochem.com
- Country
- China
- ProdList
- 21669
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48461
- Advantage
- 58
- Tel
- +86-15680926068 +86-15680926068
- 1924344760@confluore.cn
- Country
- China
- ProdList
- 2995
- Advantage
- 58
More
Less
View Lastest Price from Pomalidomide-PEG2-butyl iodide manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- Pomalidomide-2-2-6-I 1835705-72-0
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >95.00%
- Supply Ability
- 100mg
- Release date
- 2024-04-01
1835705-72-0, Pomalidomide-PEG2-butyl iodideRelated Search:
E3 ligase Ligand-Linker Conjugates 50
Pomalidomide-PEG3-CO2H
Pomalidomide-PEG4-azide
E3 Ligase Ligand-Linker Conjugates 22
4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Pomalidomide-PEG4-CO2H
E3 Ligase Ligand-Linker Conjugates 1
POMALIDOMIDE-PEG2-CO2H
Pomalidomide-PEG1-azide
Pomalidomide-PEG5-CO2H
POMALIDOMIDE-PEG1-CO2H
Pomalidomide-O-C4-NH2
Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]-
Pomalidomide-PEG3-N3
Pomalidomide-PEG6-butyl iodide
Pomalidomide-PEG2-N3