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Pomalidomide-PEG2-butyl iodide

Product Name
Pomalidomide-PEG2-butyl iodide
CAS No.
1835705-72-0
Chemical Name
Pomalidomide-PEG2-butyl iodide
Synonyms
Pomalidomide-2-2-6-I;Pomalidomide-PEG2-butyl iodide;Pomalidomide-PEG2-butyl iodide;N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-2-{2-[(6-iodohexyl)oxy]ethoxy}acetamide;Acetamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-2-[2-[(6-iodohexyl)oxy]ethoxy]-;Crosslinker–E3 Ligase ligand conjugate, Pomalidomide-2-2-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-2-(2-((6-iodohexyl)oxy)ethoxy)acetamide, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
CBNumber
CB74919985
Molecular Formula
C23H28IN3O7
Formula Weight
585.39
MOL File
1835705-72-0.mol
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Pomalidomide-PEG2-butyl iodide Property

Boiling point:
757.7±60.0 °C(Predicted)
Density 
1.588±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
powder or crystals
pka
10.68±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
904724
Product name
Pomalidomide-PEG2-butyl iodide
Purity
≥95%
Packaging
50MG
Price
$421.5
Updated
2025/07/31
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Pomalidomide-PEG2-butyl iodide Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG2-butyl Iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reactivity: sulfuryl reactive
reagent type: ligand-linker conjugate

Pomalidomide-PEG2-butyl iodide Preparation Products And Raw materials

Raw materials

Preparation Products

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Pomalidomide-PEG2-butyl iodide Suppliers

China 14 United States 1 Global 15
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
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80
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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60
Xi'an Confluore Biological Technology Co., Ltd.
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
Country
China
ProdList
4952
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58
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
Email
1927928688@qq.com
Country
China
ProdList
1615
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58
Shaanxi borno biotechnology co., LTD
Tel
+86-13759708231
Email
asherw9@hotmail.com
Country
China
ProdList
2373
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58
Zhengzhou convergence chemical co., LTD
Tel
0371-0371-55153829 18003835034
Email
2853979819@qq.com
Country
China
ProdList
9998
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ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054;
Email
trendseenbio@gmail.com
Country
China
ProdList
9069
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58
Hangzhou Bingochem Co., Ltd.
Tel
0571-8512-5372
Email
sales@bingochem.com
Country
China
ProdList
21669
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
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58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
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View Lastest Price from Pomalidomide-PEG2-butyl iodide manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Pomalidomide-2-2-6-I 1835705-72-0
Price
US $0.00/mg
Min. Order
100mg
Purity
>95.00%
Supply Ability
100mg
Release date
2024-04-01

1835705-72-0, Pomalidomide-PEG2-butyl iodideRelated Search:

E3 ligase Ligand-Linker Conjugates 50 Pomalidomide-PEG3-CO2H Pomalidomide-PEG4-azide E3 Ligase Ligand-Linker Conjugates 22 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-PEG4-CO2H E3 Ligase Ligand-Linker Conjugates 1 POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG1-azide Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG2-N3 Pomalidomide-PEG1-piperazine BI 3663

  • Pomalidomide-PEG2-butyl iodide
  • Acetamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-2-[2-[(6-iodohexyl)oxy]ethoxy]-
  • Pomalidomide-2-2-6-I
  • Crosslinker–E3 Ligase ligand conjugate, Pomalidomide-2-2-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-2-(2-((6-iodohexyl)oxy)ethoxy)acetamide, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
  • N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-2-{2-[(6-iodohexyl)oxy]ethoxy}acetamide
  • Pomalidomide-PEG<sub>2</sub>-butyl iodide
  • 1835705-72-0
  • C23H28IN3O7