Pomalidomide-PEG3-N3

Product Name: Pomalidomide-PEG3-N3
CAS No.: 2267306-15-8
Chemical Name: Pomalidomide-PEG3-N3
Synonyms: N3-PEG3-CH2CO-Poma;Pomalidomide-PEG3-N3;Pomalidomide-NH-CO-PEG3-N3;Acetamide, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG3-azide;2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
CBNumber: CB08118457
Molecular Formula: C21H24N6O8
Formula Weight: 488.46
MOL File: 2267306-15-8.mol

More

Less

Pomalidomide-PEG3-N3 Property

Melting point:: 165 °C
storage temp.: 2-8°C
solubility: DMSO: 200 mg/mL (409.46 mM)
form: Solid
color: White to yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 904678
Product name: Pomalidomide-PEG3-azide
Packaging: 50mg
Price: $464.1
Updated: 2025/07/31

Iris Biotech GmbH

Product number: PTC1540
Product name: Pomalidomid-PEG3-N3
Packaging: 50mg
Price: $607.5
Updated: 2021/12/16

More

Less

Pomalidomide-PEG3-N3 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG3-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reaction type: click chemistry
reagent type: ligand-linker conjugate

IC 50

Cereblon

Pomalidomide-PEG3-N3 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Pomalidomide-PEG3-N3 Suppliers

China 21 India 1 Global 22

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
Advantage: 58

SuZhou Medinoah Co.,LTD.

Tel: 0512-69561983 13914027025
Fax: 0512-69561982
Email: zhang_q@medinoah.com
Country: China
ProdList: 3811
Advantage: 58

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
Country: China
ProdList: 1615
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Zhengzhou Converging Chemical Co. LTD

Tel: 0371-53399770 18037166334
Email: 2853031800@qq.com
Country: China
ProdList: 5857
Advantage: 58

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054;
Email: trendseenbio@gmail.com
Country: China
ProdList: 9069
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5929
Advantage: 58

More

Less

View Lastest Price from Pomalidomide-PEG3-N3 manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Pomalidomide-NH-CO-PEG3-N3 2267306-15-8
Price: US $0.00/mg
Min. Order: 100mg
Purity: >99.00%
Supply Ability: 100mg
Release date: 2024-04-01

2267306-15-8, Pomalidomide-PEG3-N3Related Search:

Pomalidomide-PEG1-azide E3 ligase Ligand-Linker Conjugates 50 Pomalidomide-PEG3-CO2H Pomalidomide-PEG4-azide Pomalidomide-PEG2-butyl iodide E3 Ligase Ligand-Linker Conjugates 22 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-PEG4-CO2H E3 Ligase Ligand-Linker Conjugates 1 POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG2-N3 Pomalidomide-NH-CO-PEG6-N3 Pomalidomide-PEG5-N3

Pomalidomide-PEG3-N3

Pomalidomide-NH-CO-PEG3-N3

2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader

N3-PEG3-CH2CO-Poma

Acetamide, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-

2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG3-azide

2267306-15-8