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Pomalidomide-PEG2-N3

Product Name
Pomalidomide-PEG2-N3
CAS No.
2267306-14-7
Chemical Name
Pomalidomide-PEG2-N3
Synonyms
N3-PEG2-CH2CO-Poma;Pomalidomide-PEG2-N3;Pomalidomide-NH-CO-PEG2-N3;Acetamide, 2-[2-(2-azidoethoxy)ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;2-(2-(2-Azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG2-azide;2-(2-(2-Azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
CBNumber
CB78118456
Molecular Formula
C19H20N6O7
Formula Weight
444.4
MOL File
2267306-14-7.mol
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Pomalidomide-PEG2-N3 Property

Melting point:
188 °C
storage temp. 
2-8°C
solubility 
DMSO: 90 mg/mL (202.52 mM)
form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
903833
Product name
Pomalidomide-PEG2-azide
Packaging
50MG
Price
$538.2
Updated
2024/03/01
Iris Biotech GmbH
Product number
PTC1530
Product name
Pomalidomid-PEG2-N3
Packaging
50mg
Price
$607.5
Updated
2021/12/16
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Pomalidomide-PEG2-N3 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-PEG2-N3 Preparation Products And Raw materials

Raw materials

Preparation Products

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Pomalidomide-PEG2-N3 Suppliers

Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Xi'an Confluore Biological Technology Co., Ltd.
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
Country
China
ProdList
4825
Advantage
58
Jiangsu aikang biomedical research and development co., LTD
Tel
025-66110311 13155353615
Email
qzhang@aikonchem.com
Country
China
ProdList
15527
Advantage
58
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
Email
1927928688@qq.com
Country
China
ProdList
1458
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
39995
Advantage
58
Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
Country
China
ProdList
18478
Advantage
58
Zhengzhou Converging Chemical Co. LTD
Tel
0371-0371-53399770 18037166334
Email
2853031800@qq.com
Country
China
ProdList
3253
Advantage
58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054 13417589054
Email
trendseenbio@gmail.com
Country
China
ProdList
9470
Advantage
58
Shanghai Easy CDMO Co.,Ltd
Tel
021-61734564
Email
August@easycdmo.com
Country
China
ProdList
10030
Advantage
58
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View Lastest Price from Pomalidomide-PEG2-N3 manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Pomalidomide-NH-CO-PEG2-N3 2267306-14-7
Price
US $0.00/mg
Min. Order
500mg
Purity
>99.00%
Supply Ability
500mg
Release date
2024-04-01

2267306-14-7, Pomalidomide-PEG2-N3Related Search:


  • Pomalidomide-PEG2-N3
  • Pomalidomide-NH-CO-PEG2-N3
  • 2-(2-(2-Azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
  • N3-PEG2-CH2CO-Poma
  • Acetamide, 2-[2-(2-azidoethoxy)ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
  • 2-(2-(2-Azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG2-azide
  • 2267306-14-7