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Pomalidomide-PEG3-CO2H

Product Name
Pomalidomide-PEG3-CO2H
CAS No.
2138440-82-9
Chemical Name
Pomalidomide-PEG3-CO2H
Synonyms
Pomalidomide-PEG3-COOH;3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid;Poma-PEG3-COOH;Pomalidomide-PEG3-CO2H;POMALIDOMIDE-PEG 3-CO 2 H;Pomalidomide 4'-PEG3-acid;Thalidomide-NH-PEG3-C2-COOH;Pomalidomide-PEG3-CO2H >=95%;Thalidomide-4-NH-PEG3-C2-COOH;Thalidomide-NH-PEG3-propionic acid
CBNumber
CB84846411
Molecular Formula
C22H27N3O9
Formula Weight
477.46
MOL File
2138440-82-9.mol
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Pomalidomide-PEG3-CO2H Property

Boiling point:
757.8±60.0 °C(Predicted)
Density 
1.417±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO
pka
4.28±0.10(Predicted)
form 
Solid
color 
Light yellow to green yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901504
Product name
Pomalidomide-PEG3-CO2H
Purity
≥95%
Packaging
50MG
Price
$1240
Updated
2023/06/20
Iris Biotech GmbH
Product number
PTC1170
Product name
Pomalidomide-PEG3-COOH
Packaging
50mg
Price
$702
Updated
2021/12/16
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Pomalidomide-PEG3-CO2H Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG3-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

storage

Store at -20°C

Pomalidomide-PEG3-CO2H Preparation Products And Raw materials

Raw materials

Preparation Products

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Pomalidomide-PEG3-CO2H Suppliers

China 35 India 1 United Kingdom 1 United States 3 Global 40
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7195
Advantage
65
ChemShuttle, Inc.
Tel
0510-83588313-802 18800520310;
Email
sales@chemshuttle.com
Country
China
ProdList
3002
Advantage
62
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Aikon International Limited
Tel
025-66113011 18112977050
Fax
(5)02557626880
Email
cb6@aikonchem.com
Country
China
ProdList
15494
Advantage
58
Xi'an Confluore Biological Technology Co., Ltd.
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
Country
China
ProdList
4825
Advantage
58
Henan Alfachem Co.,Ltd.
Tel
0371-0371-55051623 18137891487
Fax
QQ：2853979817
Email
2853979817@qq.com
Country
China
ProdList
9908
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
Email
1927928688@qq.com
Country
China
ProdList
1458
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
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View Lastest Price from Pomalidomide-PEG3-CO2H manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Pomalidomide-PEG3-COOH 2138440-82-9
Price
US $0.00/mg
Min. Order
250mg
Purity
>99.00%
Supply Ability
250mg
Release date
2024-04-01

2138440-82-9, Pomalidomide-PEG3-CO2HRelated Search:

Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-PEG3-Amine HCl salt Pomalidomide-PEG4-CO2H E3 Ligase Ligand-Linker Conjugates 1 POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG1-azide Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione E3 Ligase Ligand-Linker Conjugates 22 Pomalidomide-PEG2-butyl iodide Pomalidomide-PEG4-azide Pomalidomide-PEG2-N3 E3 ligase Ligand-Linker Conjugates 50 Pomalidomide-PEG5-Alkyne

  • POMALIDOMIDE-PEG 3-CO 2 H
  • Pomalidomide-PEG3-CO2H
  • 3-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid
  • Propanoic acid, 3-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]-
  • Pomalidomide-PEG3-COOH
  • Pomalidomide-PEG3-CO2H >=95%
  • 3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid
  • Thalidomide-NH-PEG3-propionic acid
  • Thalidomide-NH-PEG3-C2-COOH
  • 3-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]ethoxy]ethoxy]propanoic Acid
  • Thalidomide-4-NH-PEG3-C2-COOH
  • Poma-PEG3-COOH
  • Pomalidomide 4'-PEG3-acid
  • 3-{2-[2-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]ethoxy}propanoic acid
  • 2138440-82-9
  • C22H27N3O9
  • peg