E3 ligase Ligand-Linker Conjugates 50
- Product Name
- E3 ligase Ligand-Linker Conjugates 50
- CAS No.
- 2271036-44-1
- Chemical Name
- E3 ligase Ligand-Linker Conjugates 50
- Synonyms
- Poma-PEG1-N3;Pomalidomide-PEG1-C2-N3;Pomalidomide 4'-PEG1-azide;Cereblon Ligand-Linker Conjugates 13;E3 ligase Ligand-Linker Conjugates 50;Pomalidomide-PEG1-C2-azide;4-[2-(2-azidoethoxy)ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-;1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
- CBNumber
- CB96127047
- Molecular Formula
- C17H18N6O5
- Formula Weight
- 386.37
- MOL File
- 2271036-44-1.mol
E3 ligase Ligand-Linker Conjugates 50 Property
- storage temp.
- -20°C, stored under nitrogen
- form
- Solid
- color
- Light yellow to yellow
E3 ligase Ligand-Linker Conjugates 50 Chemical Properties,Usage,Production
Uses
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1]. Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Biological Activity
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].
IC 50
Cereblon
storage
Store at -20°C
References
[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.
E3 ligase Ligand-Linker Conjugates 50 Preparation Products And Raw materials
Raw materials
Preparation Products
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