E3 ligase Ligand-Linker Conjugates 13

Product Name: E3 ligase Ligand-Linker Conjugates 13
CAS No.: 2010159-45-0
Chemical Name: E3 ligase Ligand-Linker Conjugates 13
Synonyms: VH032-PEG2-N3;S)-AHPC-PEG2-N3;(S,R,S)-AHPC-PEG2-azide;VHL Ligand-Linker Conjugates 6;E3 ligase Ligand-Linker Conjugates 13;E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG2N3,Inhibitor,inhibit,(S,R,S)-AHPC-PEG-2-N3,(S,R,S) AHPC PEG2 N3;(2S,4R)-1-((S)-2-(2-(2-(2-Azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
CBNumber: CB93386465
Molecular Formula: C28H39N7O6S
Formula Weight: 601.72
MOL File: 2010159-45-0.mol

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E3 ligase Ligand-Linker Conjugates 13 Property

storage temp.: 2-8°C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 904813
Product name: (S,R,S)-AHPC-PEG2-azide
Packaging: 50MG
Price: $1290
Updated: 2023/06/20

Iris Biotech GmbH

Product number: PTC1600
Product name: (S,R,S)-AHPC-PEG2-N3
Packaging: 50mg
Price: $634.5
Updated: 2021/12/16

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E3 ligase Ligand-Linker Conjugates 13 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

E3 ligase Ligand-Linker Conjugates 13 Preparation Products And Raw materials

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E3 ligase Ligand-Linker Conjugates 13 Suppliers

China 15 United States 1 Global 16

Sigma-Aldrich

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Shanghai Chaolan Chemical Technology Center

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Xi'an Confluore Biological Technology Co., Ltd.

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TargetMol Chemicals Inc.

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View Lastest Price from E3 ligase Ligand-Linker Conjugates 13 manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (S,R,S)-AHPC-PEG2-azide 2010159-45-0
Price: US $0.00/mg
Min. Order: 100mg
Purity: >99.00%
Supply Ability: 100mg
Release date: 2024-04-01

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E3 ligase Ligand-Linker Conjugates 13

(S,R,S)-AHPC-PEG2-azide

VHL Ligand-Linker Conjugates 6

VH032-PEG2-N3

S)-AHPC-PEG2-N3

E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG2N3,Inhibitor,inhibit,(S,R,S)-AHPC-PEG-2-N3,(S,R,S) AHPC PEG2 N3

(2S,4R)-1-((S)-2-(2-(2-(2-Azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate

2010159-45-0