E3 ligase Ligand-Linker Conjugates 7 Free Base
- Product Name
- E3 ligase Ligand-Linker Conjugates 7 Free Base
- CAS No.
- 2010159-57-4
- Chemical Name
- E3 ligase Ligand-Linker Conjugates 7 Free Base
- Synonyms
- VH032-PEG4-NH2;PROTACs Related Compound 8;VHL Ligand-Linker Conjugates 4;(S,R,S)-AHPC-PEG?-NH? hydrochloride;(S,R. S)-AHPC-PEG4-amine hydrochloride salt;E3 ligase Ligand-Linker Conjugates 7 Free Base;(S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7);L-Prolinamide, N-(14-amino-1-oxo-3,6,9,12-tetraoxatetradec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl]pyrrolidine-2-carboxamide
- CBNumber
- CB74797053
- Molecular Formula
- C32H49N5O8S
- Formula Weight
- 663.83
- MOL File
- 2010159-57-4.mol
E3 ligase Ligand-Linker Conjugates 7 Free Base Property
- Boiling point:
- 901.7±65.0 °C(Predicted)
- Density
- 1.230±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in Water, DMSO, Methanol
- pka
- 13.54±0.46(Predicted)
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 901848
- Product name
- (S,R,S)-AHPC-PEG4-NH2 hydrochloride
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $452
- Updated
- 2024/03/01
- Product number
- BP-24446
- Product name
- (S,R.S)-AHPC-PEG4-aminehydrochloridesalt
- Purity
- 98%
- Packaging
- 250mg
- Price
- $960
- Updated
- 2021/12/16
- Product number
- 027595
- Product name
- (S,R,S)-AHPC-PEG4-NH2(E3ligaseLigand-LinkerConjugates7)
- Packaging
- 003
- Price
- $1000
- Updated
- 2021/12/16
- Product number
- 027595
- Product name
- (S,R,S)-AHPC-PEG4-NH2(E3ligaseLigand-LinkerConjugates7)
- Packaging
- 002
- Price
- $500
- Updated
- 2021/12/16
E3 ligase Ligand-Linker Conjugates 7 Free Base Chemical Properties,Usage,Production
Description
(S, R, S)-AHPC-PEG4-amine is a PROTAC linker that incorporates an E3 ligase ligand with a PEG4 unit to empower drug research & discovery. The amine group is reactive with NHS ester or carboxylic acid.
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG4-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
E3 ligase Ligand-Linker Conjugates 7 Free Base Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from E3 ligase Ligand-Linker Conjugates 7 Free Base manufacturers
- Product
- (S,R,S)-AHPC-PEG4-NH2 2010159-57-4
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >98.00%
- Supply Ability
- 100mg
- Release date
- 2024-04-01