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E3 ligase Ligand-Linker Conjugates 7 Free Base

Product Name
E3 ligase Ligand-Linker Conjugates 7 Free Base
CAS No.
2010159-57-4
Chemical Name
E3 ligase Ligand-Linker Conjugates 7 Free Base
Synonyms
VH032-PEG4-NH2;PROTACs Related Compound 8;VHL Ligand-Linker Conjugates 4;(S,R,S)-AHPC-PEG?-NH? hydrochloride;(S,R. S)-AHPC-PEG4-amine hydrochloride salt;E3 ligase Ligand-Linker Conjugates 7 Free Base;(S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7);L-Prolinamide, N-(14-amino-1-oxo-3,6,9,12-tetraoxatetradec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl]pyrrolidine-2-carboxamide
CBNumber
CB74797053
Molecular Formula
C32H49N5O8S
Formula Weight
663.83
MOL File
2010159-57-4.mol
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E3 ligase Ligand-Linker Conjugates 7 Free Base Property

Boiling point:
901.7±65.0 °C(Predicted)
Density 
1.230±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in Water, DMSO, Methanol
pka
13.54±0.46(Predicted)
form 
Solid
color 
White to off-white
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Safety

HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901848
Product name
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
Purity
≥95%
Packaging
50mg
Price
$452
Updated
2024/03/01
BroadPharm
Product number
BP-24446
Product name
(S,R.S)-AHPC-PEG4-aminehydrochloridesalt
Purity
98%
Packaging
250mg
Price
$960
Updated
2021/12/16
DC Chemicals
Product number
027595
Product name
(S,R,S)-AHPC-PEG4-NH2(E3ligaseLigand-LinkerConjugates7)
Packaging
003
Price
$1000
Updated
2021/12/16
DC Chemicals
Product number
027595
Product name
(S,R,S)-AHPC-PEG4-NH2(E3ligaseLigand-LinkerConjugates7)
Packaging
002
Price
$500
Updated
2021/12/16
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E3 ligase Ligand-Linker Conjugates 7 Free Base Chemical Properties,Usage,Production

Description

(S, R, S)-AHPC-PEG4-amine is a PROTAC linker that incorporates an E3 ligase ligand with a PEG4 unit to empower drug research & discovery. The amine group is reactive with NHS ester or carboxylic acid.

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG4-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

E3 ligase Ligand-Linker Conjugates 7 Free Base Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 ligase Ligand-Linker Conjugates 7 Free Base Suppliers

China 23 United States 2 Global 25
Sigma-Aldrich
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Xi'an Confluore Biological Technology Co., Ltd.
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Changzhou Bojia Biomedical Technology Co., Ltd.
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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
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Henan Alpha Chemical Co., Ltd.
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Wuhan Yuxiang Medical Technology Co., Ltd.
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ShenZhen Trendseen Biological Technology Co.,Ltd.
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Xian confluore Biological Technology Co., Ltd.
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View Lastest Price from E3 ligase Ligand-Linker Conjugates 7 Free Base manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
(S,R,S)-AHPC-PEG4-NH2 2010159-57-4
Price
US $0.00/mg
Min. Order
100mg
Purity
>98.00%
Supply Ability
100mg
Release date
2024-04-01

2010159-57-4, E3 ligase Ligand-Linker Conjugates 7 Free BaseRelated Search:

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  • E3 ligase Ligand-Linker Conjugates 7 Free Base
  • VH032-PEG4-NH2
  • VHL Ligand-Linker Conjugates 4
  • PROTACs Related Compound 8
  • (S,R. S)-AHPC-PEG4-amine hydrochloride salt
  • L-Prolinamide, N-(14-amino-1-oxo-3,6,9,12-tetraoxatetradec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
  • (S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7)
  • (2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
  • (2S,4R)-1-[(S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl]pyrrolidine-2-carboxamide
  • (2S,4R)-1-((S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
  • (S,R,S)-AHPC-PEG?-NH? hydrochloride
  • (2s,4R)-1-[(2s)-2-[[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]acetyl]amino]-3.3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
  • (2S,4R)-1-[(2S)-2-(14-amino-3,6,9,12-tetraoxatetradecanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
  • 2010159-57-4
  • C32H49N5O8S