E3 ligase Ligand-Linker Conjugates 7 Free Base

Product Name: E3 ligase Ligand-Linker Conjugates 7 Free Base
CAS No.: 2010159-57-4
Chemical Name: E3 ligase Ligand-Linker Conjugates 7 Free Base
Synonyms: VH032-PEG4-NH2;PROTACs Related Compound 8;VHL Ligand-Linker Conjugates 4;(S,R,S)-AHPC-PEG?-NH? hydrochloride;(S,R. S)-AHPC-PEG4-amine hydrochloride salt;E3 ligase Ligand-Linker Conjugates 7 Free Base;(S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7);L-Prolinamide, N-(14-amino-1-oxo-3,6,9,12-tetraoxatetradec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl]pyrrolidine-2-carboxamide
CBNumber: CB74797053
Molecular Formula: C32H49N5O8S
Formula Weight: 663.83
MOL File: 2010159-57-4.mol

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E3 ligase Ligand-Linker Conjugates 7 Free Base Property

Boiling point:: 901.7±65.0 °C(Predicted)
Density: 1.230±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in Water, DMSO, Methanol
pka: 13.54±0.46(Predicted)
form: Solid
color: White to off-white

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Safety

HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 901848
Product name: (S,R,S)-AHPC-PEG4-NH2 hydrochloride
Purity: ≥95%
Packaging: 50mg
Price: $452
Updated: 2024/03/01

BroadPharm

Product number: BP-24446
Product name: (S,R.S)-AHPC-PEG4-aminehydrochloridesalt
Purity: 98%
Packaging: 250mg
Price: $960
Updated: 2021/12/16

DC Chemicals

Product number: 027595
Product name: (S,R,S)-AHPC-PEG4-NH2(E3ligaseLigand-LinkerConjugates7)
Packaging: 003
Price: $1000
Updated: 2021/12/16

DC Chemicals

Product number: 027595
Product name: (S,R,S)-AHPC-PEG4-NH2(E3ligaseLigand-LinkerConjugates7)
Packaging: 002
Price: $500
Updated: 2021/12/16

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E3 ligase Ligand-Linker Conjugates 7 Free Base Chemical Properties,Usage,Production

Description

(S, R, S)-AHPC-PEG4-amine is a PROTAC linker that incorporates an E3 ligase ligand with a PEG4 unit to empower drug research & discovery. The amine group is reactive with NHS ester or carboxylic acid.

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG₄-NH₂ (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

E3 ligase Ligand-Linker Conjugates 7 Free Base Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 ligase Ligand-Linker Conjugates 7 Free Base Suppliers

China 23 United States 2 Global 25

Sigma-Aldrich

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Xi'an Confluore Biological Technology Co., Ltd.

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Jiangsu aikang biomedical research and development co., LTD

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TargetMol Chemicals Inc.

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DC Chemicals

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Shanghai hongqu biomedical technology co. LTD

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Energy Chemical

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Zhengzhou Akem Chemical Co., Ltd

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View Lastest Price from E3 ligase Ligand-Linker Conjugates 7 Free Base manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (S,R,S)-AHPC-PEG4-NH2 2010159-57-4
Price: US $0.00/mg
Min. Order: 100mg
Purity: >98.00%
Supply Ability: 100mg
Release date: 2024-04-01

2010159-57-4, E3 ligase Ligand-Linker Conjugates 7 Free BaseRelated Search:

E3 ligase Ligand-Linker Conjugates 50 E3 Ligase Ligand-Linker Conjugates 21 E3 ligase Ligand-Linker Conjugates 13 E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate E3 ligase Ligand-Linker Conjugates 4 E3 ligase Ligand-Linker Conjugates 6 E3 Ligase Ligand-Linker Conjugates 19 E3 Ligase Ligand-Linker Conjugates 22 E3 ligase Ligand-Linker Conjugates 11

E3 ligase Ligand-Linker Conjugates 7 Free Base

VH032-PEG4-NH2

VHL Ligand-Linker Conjugates 4

PROTACs Related Compound 8

(S,R. S)-AHPC-PEG4-amine hydrochloride salt

L-Prolinamide, N-(14-amino-1-oxo-3,6,9,12-tetraoxatetradec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

(S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7)

(2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

(2S,4R)-1-[(S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl]pyrrolidine-2-carboxamide

(2S,4R)-1-((S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate

(S,R,S)-AHPC-PEG?-NH? hydrochloride

(2s,4R)-1-[(2s)-2-[[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]acetyl]amino]-3.3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

(2S,4R)-1-[(2S)-2-(14-amino-3,6,9,12-tetraoxatetradecanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

2010159-57-4

C32H49N5O8S