E3 ligase Ligand-Linker Conjugates 11
- Product Name
- E3 ligase Ligand-Linker Conjugates 11
- CAS No.
- 1835705-61-7
- Chemical Name
- E3 ligase Ligand-Linker Conjugates 11
- Synonyms
- (S,R,S)-AHPC-6-5-6-Cl;(S,R,S)-AHPC-(C3-PEG)2-C6-C;VHL Ligand-Linker Conjugates 11;E3 ligase Ligand-Linker Conjugates 11;(S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride;L-Prolinamide, N-[6-[[5-[(6-chlorohexyl)oxy]pentyl]oxy]-1-oxohexyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
- CBNumber
- CB63386464
- Molecular Formula
- C39H61ClN4O6S
- Formula Weight
- 749.44
- MOL File
- 1835705-61-7.mol
E3 ligase Ligand-Linker Conjugates 11 Property
- Boiling point:
- 921.3±65.0 °C(Predicted)
- Density
- 1.152±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.08±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 905402
- Product name
- (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride
- Purity
- 95%
- Packaging
- 50MG
- Price
- $559
- Updated
- 2023/06/20
- Product number
- PTC1760
- Product name
- (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl-Cl
- Packaging
- 50mg
- Price
- $634.5
- Updated
- 2021/12/16
E3 ligase Ligand-Linker Conjugates 11 Chemical Properties,Usage,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
E3 ligase Ligand-Linker Conjugates 11 Preparation Products And Raw materials
Raw materials
Preparation Products
E3 ligase Ligand-Linker Conjugates 11 Suppliers
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View Lastest Price from E3 ligase Ligand-Linker Conjugates 11 manufacturers
- Product
- (S,R,S)-AHPC-6-5-6-Cl 1835705-61-7
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >95.00%
- Supply Ability
- 1g
- Release date
- 2024-04-01