E3 ligase Ligand-Linker Conjugates 13
- Product Name
- E3 ligase Ligand-Linker Conjugates 13
- CAS No.
- 2010159-45-0
- Chemical Name
- E3 ligase Ligand-Linker Conjugates 13
- Synonyms
- VH032-PEG2-N3;S)-AHPC-PEG2-N3;(S,R,S)-AHPC-PEG2-azide;VHL Ligand-Linker Conjugates 6;E3 ligase Ligand-Linker Conjugates 13;E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG2N3,Inhibitor,inhibit,(S,R,S)-AHPC-PEG-2-N3,(S,R,S) AHPC PEG2 N3;L-Prolinamide, N-[2-[2-(2-azidoethoxy)ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(2-(2-(2-azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-2-(2-(2-(2-Azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
- CBNumber
- CB93386465
- Molecular Formula
- C28H39N7O6S
- Formula Weight
- 601.72
- MOL File
- 2010159-45-0.mol
E3 ligase Ligand-Linker Conjugates 13 Property
- storage temp.
- 2-8°C
- form
- Liquid
- color
- Off-white to yellow
N-Bromosuccinimide Price
- Product number
- 904813
- Product name
- (S,R,S)-AHPC-PEG2-azide
- Packaging
- 50MG
- Price
- $1290
- Updated
- 2023/06/20
- Product number
- PTC1600
- Product name
- (S,R,S)-AHPC-PEG2-N3
- Packaging
- 50mg
- Price
- $634.5
- Updated
- 2021/12/16
E3 ligase Ligand-Linker Conjugates 13 Chemical Properties,Usage,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
E3 ligase Ligand-Linker Conjugates 13 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from E3 ligase Ligand-Linker Conjugates 13 manufacturers
- Product
- (S,R,S)-AHPC-PEG2-azide 2010159-45-0
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >99.00%
- Supply Ability
- 100mg
- Release date
- 2024-04-01