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E3 ligase Ligand-Linker Conjugates 13

Product Name
E3 ligase Ligand-Linker Conjugates 13
CAS No.
2010159-45-0
Chemical Name
E3 ligase Ligand-Linker Conjugates 13
Synonyms
VH032-PEG2-N3;S)-AHPC-PEG2-N3;(S,R,S)-AHPC-PEG2-azide;VHL Ligand-Linker Conjugates 6;E3 ligase Ligand-Linker Conjugates 13;E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG2N3,Inhibitor,inhibit,(S,R,S)-AHPC-PEG-2-N3,(S,R,S) AHPC PEG2 N3;L-Prolinamide, N-[2-[2-(2-azidoethoxy)ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(2-(2-(2-azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-2-(2-(2-(2-Azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
CBNumber
CB93386465
Molecular Formula
C28H39N7O6S
Formula Weight
601.72
MOL File
2010159-45-0.mol
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E3 ligase Ligand-Linker Conjugates 13 Property

storage temp. 
2-8°C
form 
Liquid
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
904813
Product name
(S,R,S)-AHPC-PEG2-azide
Packaging
50MG
Price
$1290
Updated
2023/06/20
Iris Biotech GmbH
Product number
PTC1600
Product name
(S,R,S)-AHPC-PEG2-N3
Packaging
50mg
Price
$634.5
Updated
2021/12/16
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E3 ligase Ligand-Linker Conjugates 13 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

E3 ligase Ligand-Linker Conjugates 13 Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 ligase Ligand-Linker Conjugates 13 Suppliers

Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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Xi'an Confluore Biological Technology Co., Ltd.
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+86-156-80926068 +86-15680926068
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1924344760@qq.com
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China
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4825
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Jilin Province Woda Biotechnology Co., Ltd.
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13504435624
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1927928688@qq.com
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China
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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Shanghai Kaiwei Chemical Technology Co., Ltd.
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021-58461859 15821823057
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service@aiviche.com
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China
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Shanghai hongqu biomedical technology co. LTD
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88888888888
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hongquchem@qq.com
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China
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Shanghai Haohong Pharmaceutical Co., Ltd.
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Bide Pharmatech Ltd.
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Changzhou Bojia Biomedical Technology Co., Ltd.
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2122619822
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czbjpharma@126.com
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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Henan Alpha Chemical Co., Ltd.
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0371-55013243 15324716602
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2853979810@qq.com
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Wuhan Yuxiang Medical Technology Co., Ltd.
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ShenZhen Trendseen Biological Technology Co.,Ltd.
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Beijing Solarbio Science & Tecnology Co., Ltd.
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66113011 18112977050
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Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
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021-59167510 18117107507
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vip@med-life.cn
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China
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Xian confluore Biological Technology Co., Ltd.
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1924344760@confluore.cn
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China
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2996
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View Lastest Price from E3 ligase Ligand-Linker Conjugates 13 manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
(S,R,S)-AHPC-PEG2-azide 2010159-45-0
Price
US $0.00/mg
Min. Order
100mg
Purity
>99.00%
Supply Ability
100mg
Release date
2024-04-01

2010159-45-0, E3 ligase Ligand-Linker Conjugates 13Related Search:


  • E3 ligase Ligand-Linker Conjugates 13
  • (S,R,S)-AHPC-PEG2-azide
  • VHL Ligand-Linker Conjugates 6
  • VH032-PEG2-N3
  • S)-AHPC-PEG2-N3
  • E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG2N3,Inhibitor,inhibit,(S,R,S)-AHPC-PEG-2-N3,(S,R,S) AHPC PEG2 N3
  • (2S,4R)-1-((S)-2-(2-(2-(2-Azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
  • (2S,4R)-1-((S)-2-(2-(2-(2-azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
  • L-Prolinamide, N-[2-[2-(2-azidoethoxy)ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
  • 2010159-45-0