E3 ligase Ligand-Linker Conjugates 50

Product Name: E3 ligase Ligand-Linker Conjugates 50
CAS No.: 2271036-44-1
Chemical Name: E3 ligase Ligand-Linker Conjugates 50
Synonyms: Poma-PEG1-N3;Pomalidomide-PEG1-C2-N3;Cereblon Ligand-Linker Conjugates 13;E3 ligase Ligand-Linker Conjugates 50;4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-;1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
CBNumber: CB96127047
Molecular Formula: C17H18N6O5
Formula Weight: 386.37
MOL File: 2271036-44-1.mol

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E3 ligase Ligand-Linker Conjugates 50 Property

storage temp.: -20°C, stored under nitrogen
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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E3 ligase Ligand-Linker Conjugates 50 Chemical Properties,Usage,Production

Biological Activity

Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].

storage

Store at -20°C

References

[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.

E3 ligase Ligand-Linker Conjugates 50 Preparation Products And Raw materials

Raw materials

Preparation Products

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2271036-44-1, E3 ligase Ligand-Linker Conjugates 50Related Search:

Pomalidomide-PEG4-CO2H E3 Ligase Ligand-Linker Conjugates 1 POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG1-azide Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide E3 Ligase Ligand-Linker Conjugates 21 E3 ligase Ligand-Linker Conjugates 13 E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate E3 ligase Ligand-Linker Conjugates 4 E3 ligase Ligand-Linker Conjugates 6 E3 Ligase Ligand-Linker Conjugates 19 E3 ligase Ligand-Linker Conjugates 7 Free Base E3 Ligase Ligand-Linker Conjugates 22

E3 ligase Ligand-Linker Conjugates 50

Cereblon Ligand-Linker Conjugates 13

Pomalidomide-PEG1-C2-N3

4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

Poma-PEG1-N3

1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-

2271036-44-1