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Pomalidomide-PEG4-CO2H

Product Name
Pomalidomide-PEG4-CO2H
CAS No.
2138440-81-8
Chemical Name
Pomalidomide-PEG4-CO2H
Synonyms
Pomalidomide-PEG4-COOH;Poma-PEG4-COOH;Pomalidomide-PEG4-CO2H;POMALIDOMIDE-PEG4-CO 2 H;Pomalidomide 4'-PEG4-acid;Thalidomide-NH-PEG4-C2-COOH;1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid;1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid;1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxapentadecan-15-oic acid;Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-
CBNumber
CB54846410
Molecular Formula
C24H31N3O10
Formula Weight
521.52
MOL File
2138440-81-8.mol
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Pomalidomide-PEG4-CO2H Property

Boiling point:
773.6±60.0 °C(Predicted)
Density 
1.385±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.28±0.10(Predicted)
form 
Viscous Liquid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901824
Product name
Pomalidomide-PEG4-CO2H
Packaging
50MG
Price
$358.2
Updated
2024/03/01
Iris Biotech GmbH
Product number
PTC1180
Product name
Pomalidomide-PEG4-COOH
Packaging
50mg
Price
$594
Updated
2021/12/16
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Pomalidomide-PEG4-CO2H Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG4-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition and E3 ligase ligand.

storage

Desiccate at RT

Pomalidomide-PEG4-CO2H Preparation Products And Raw materials

Raw materials

Preparation Products

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Pomalidomide-PEG4-CO2H Suppliers

China 24 United States 1 Global 25
ChemShuttle, Inc.
Tel
0510-83588313-802 18800520310;
Email
sales@chemshuttle.com
Country
China
ProdList
2996
Advantage
62
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Aikon International Limited
Tel
025-58851090 13611564524
Fax
(6)02557626880
Email
lwan@aikonchem.com
Country
China
ProdList
15951
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
16474
Advantage
58
Xi'an Confluore Biological Technology Co., Ltd.
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
Country
China
ProdList
4824
Advantage
58
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
Email
1927928688@qq.com
Country
China
ProdList
1456
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD
Tel
025-86755008 17751752005
Fax
025-86755228
Email
hszhang@bestfluorodrug.com
Country
China
ProdList
2358
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40037
Advantage
58
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View Lastest Price from Pomalidomide-PEG4-CO2H manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Pomalidomide-PEG4-COOH 2138440-81-8
Price
US $0.00/mg
Min. Order
250mg
Purity
>98.00%
Supply Ability
250mg
Release date
2024-04-01

2138440-81-8, Pomalidomide-PEG4-CO2HRelated Search:

E3 Ligase Ligand-Linker Conjugates 1 POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG1-azide Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-PEG3-Amine HCl salt Pomalidomide-PEG3-CO2H 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione E3 Ligase Ligand-Linker Conjugates 22 Pomalidomide-PEG2-butyl iodide Pomalidomide-PEG4-azide Pomalidomide-PEG2-N3 E3 ligase Ligand-Linker Conjugates 50 POMALIDOMIDE-PEG1-ALKYNE

  • POMALIDOMIDE-PEG4-CO 2 H
  • Pomalidomide-PEG4-CO2H
  • Pomalidomide-PEG4-COOH
  • 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid
  • Thalidomide-NH-PEG4-C2-COOH
  • Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-
  • 1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid
  • 1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
  • Poma-PEG4-COOH
  • Pomalidomide 4'-PEG4-acid
  • 1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxapentadecan-15-oic acid
  • 2138440-81-8
  • peg