Pomalidomide-PEG4-CO2H

Product Name: Pomalidomide-PEG4-CO2H
CAS No.: 2138440-81-8
Chemical Name: Pomalidomide-PEG4-CO2H
Synonyms: Pomalidomide-PEG4-COOH;Poma-PEG4-COOH;Pomalidomide-PEG4-CO2H;POMALIDOMIDE-PEG4-CO 2 H;Pomalidomide 4'-PEG4-acid;Thalidomide-NH-PEG4-C2-COOH;1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid;1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid;1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxapentadecan-15-oic acid;Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-
CBNumber: CB54846410
Molecular Formula: C24H31N3O10
Formula Weight: 521.52
MOL File: 2138440-81-8.mol

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Pomalidomide-PEG4-CO2H Property

Boiling point:: 773.6±60.0 °C(Predicted)
Density: 1.385±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.28±0.10(Predicted)
form: Viscous Liquid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 901824
Product name: Pomalidomide-PEG4-CO2H
Packaging: 50MG
Price: $358.2
Updated: 2024/03/01

Iris Biotech GmbH

Product number: PTC1180
Product name: Pomalidomide-PEG4-COOH
Packaging: 50mg
Price: $594
Updated: 2021/12/16

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Pomalidomide-PEG4-CO2H Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG₄-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition and E3 ligase ligand.

reaction suitability

reactivity: amine reactive
reagent type: ligand-linker conjugate

storage

Desiccate at RT

Pomalidomide-PEG4-CO2H Preparation Products And Raw materials

Raw materials

Preparation Products

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Pomalidomide-PEG4-CO2H Suppliers

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View Lastest Price from Pomalidomide-PEG4-CO2H manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Pomalidomide-PEG4-COOH 2138440-81-8
Price: US $0.00/mg
Min. Order: 250mg
Purity: >98.00%
Supply Ability: 250mg
Release date: 2024-04-01

2138440-81-8, Pomalidomide-PEG4-CO2HRelated Search:

E3 Ligase Ligand-Linker Conjugates 1 POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG1-azide Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-PEG3-Amine HCl salt Pomalidomide-PEG3-CO2H 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione E3 Ligase Ligand-Linker Conjugates 22 Pomalidomide-PEG2-butyl iodide Pomalidomide-PEG4-azide Pomalidomide-PEG2-N3 E3 ligase Ligand-Linker Conjugates 50 POMALIDOMIDE-PEG1-ALKYNE

POMALIDOMIDE-PEG4-CO 2 H

Pomalidomide-PEG4-CO2H

Pomalidomide-PEG4-COOH

1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid

Thalidomide-NH-PEG4-C2-COOH

Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-

1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid

1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader

Poma-PEG4-COOH

Pomalidomide 4'-PEG4-acid

1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxapentadecan-15-oic acid

2138440-81-8

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