Pomalidomide-PEG2-N3
- Product Name
- Pomalidomide-PEG2-N3
- CAS No.
- 2267306-14-7
- Chemical Name
- Pomalidomide-PEG2-N3
- Synonyms
- N3-PEG2-CH2CO-Poma;Pomalidomide-PEG2-N3;Pomalidomide-NH-CO-PEG2-N3;Acetamide, 2-[2-(2-azidoethoxy)ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;2-(2-(2-Azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG2-azide;2-(2-(2-Azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
- CBNumber
- CB78118456
- Molecular Formula
- C19H20N6O7
- Formula Weight
- 444.4
- MOL File
- 2267306-14-7.mol
Pomalidomide-PEG2-N3 Property
- Melting point:
- 188 °C
- storage temp.
- 2-8°C
- solubility
- DMSO: 90 mg/mL (202.52 mM)
- form
- Solid
- color
- Off-white to light yellow
N-Bromosuccinimide Price
- Product number
- 903833
- Product name
- Pomalidomide-PEG2-azide
- Packaging
- 50MG
- Price
- $538.2
- Updated
- 2024/03/01
- Product number
- PTC1530
- Product name
- Pomalidomid-PEG2-N3
- Packaging
- 50mg
- Price
- $607.5
- Updated
- 2021/12/16
Pomalidomide-PEG2-N3 Chemical Properties,Usage,Production
Uses
Protein degrader builiding block Pomalidomide-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Pomalidomide-PEG2-N3 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pomalidomide-PEG2-N3 manufacturers
- Product
- Pomalidomide-NH-CO-PEG2-N3 2267306-14-7
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >99.00%
- Supply Ability
- 500mg
- Release date
- 2024-04-01