BI 3663

Product Name: BI 3663
CAS No.: 2341740-84-7
Chemical Name: BI 3663
Synonyms: BI 3663);BI-3663 (BI3663;N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-3-{2-[2-(2-{[3-methoxy-4-({4-[(3-oxo-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl}amino)phenyl]formamido}ethoxy)ethoxy]ethoxy}propanamide;Benzamide, 4-[[4-[(2,3-dihydro-3-oxo-1H-inden-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-N-[2-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethyl]-3-methoxy-
CBNumber: CB74844551
Molecular Formula: C44H42F3N7O12
Formula Weight: 917.84
MOL File: 2341740-84-7.mol

More

Less

BI 3663 Property

Density: 1.456±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 300 mg/mL (326.85 mM; Need ultrasonic)
form: Solid
pka: 10.69±0.40(Predicted)
color: Light yellow to yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0087090
Product name: BI-3663
Purity: 98.14%
Packaging: 1mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0087090
Product name: BI-3663
Purity: 98.14%
Packaging: 5mg
Price: $1400
Updated: 2021/12/16

ChemScene

Product number: CS-0087090
Product name: BI-3663
Purity: 98.14%
Packaging: 10mg
Price: $2400
Updated: 2021/12/16

More

Less

BI 3663 Chemical Properties,Usage,Production

Uses

BI-3663 is a highly selective PTK2/FAK PROTAC (DC50=30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 (HY-124625) linked to Pomalidomide (HY-10984) with a linker[1]. Anti-cancer activity[1].

IC 50

PTK2/FAK: 18 nM (IC₅₀); Cereblon

References

[1] Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. DOI:10.1021/acs.jmedchem.8b01826

BI 3663 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

BI 3663 Suppliers

China 16 United States 4 Global 20

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
Country: China
ProdList: 1615
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988941452
Fax: QQ：3283937693
Email: YN_research@163.com
Country: China
ProdList: 3011
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054;
Email: trendseenbio@gmail.com
Country: China
ProdList: 9069
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5929
Advantage: 58

2341740-84-7, BI 3663Related Search:

Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG1-piperazine Pomalidomide-PEG2-butyl iodide Pomalidomide-C6-PEG3-butyl iodide Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide

BI 3663)

BI-3663 (BI3663

Benzamide, 4-[[4-[(2,3-dihydro-3-oxo-1H-inden-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-N-[2-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethyl]-3-methoxy-

N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-3-{2-[2-(2-{[3-methoxy-4-({4-[(3-oxo-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl}amino)phenyl]formamido}ethoxy)ethoxy]ethoxy}propanamide

2341740-84-7