Pomalidomide-C6-PEG3-butyl iodide

Product Name: Pomalidomide-C6-PEG3-butyl iodide
CAS No.: 1835705-70-8
Chemical Name: Pomalidomide-C6-PEG3-butyl iodide
Synonyms: Poma-6-2-2-6-I;Pomalidomide-6-2-2-6-I;Pomalidomide-C6-PEG3-butyl iodide;N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]-6-[2-[2-(6-iodohexoxy)ethoxy]ethoxy]hexanamide;Hexanamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-6-[2-[2-[(6-iodohexyl)oxy]ethoxy]ethoxy]-;N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-6-(2-(2-((6-iodohexyl)oxy)ethoxy)ethoxy)hexanamide, Crosslinker?E3 Ligase ligand conjugate, Pomalidomide-6-2-2-6-I, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
CBNumber: CB75430559
Molecular Formula: C29H40IN3O8
Formula Weight: 685.55
MOL File: 1835705-70-8.mol

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Pomalidomide-C6-PEG3-butyl iodide Property

Boiling point:: 813.9±65.0 °C(Predicted)
Density: 1.446±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 10.69±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 904708
Product name: Pomalidomide-C6-PEG3-butyl iodide
Purity: ≥95%
Packaging: 50MG
Price: $473
Updated: 2023/06/20

Iris Biotech GmbH

Product number: PTC1700
Product name: Pomalidomid-C6-PEG3-butyl-I
Packaging: 50mg
Price: $567
Updated: 2021/12/16

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Pomalidomide-C6-PEG3-butyl iodide Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-C₆-PEG₃-butyl iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-C6-PEG3-butyl iodide Preparation Products And Raw materials

Raw materials

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Pomalidomide-C6-PEG3-butyl iodide Suppliers

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View Lastest Price from Pomalidomide-C6-PEG3-butyl iodide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Pomalidomide-6-2-2-6-I 1835705-70-8
Price: US $0.00/mg
Min. Order: 100mg
Purity: >95.00%
Supply Ability: 100mg
Release date: 2024-04-01

1835705-70-8, Pomalidomide-C6-PEG3-butyl iodideRelated Search:

E3 ligase Ligand-Linker Conjugates 49 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl E3 ligase Ligand-Linker Conjugates 55 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Pomalidomide-6-2-2-6-N3 Pomalidomide-amido-C1-Br Pomalidomide-C6-NH2?hydrochloride Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide POMALIDOMIDE-C9-CO2H

Pomalidomide-C6-PEG3-butyl iodide

Pomalidomide-6-2-2-6-I

N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]-6-[2-[2-(6-iodohexoxy)ethoxy]ethoxy]hexanamide

Hexanamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-6-[2-[2-[(6-iodohexyl)oxy]ethoxy]ethoxy]-

N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-6-(2-(2-((6-iodohexyl)oxy)ethoxy)ethoxy)hexanamide, Crosslinker?E3 Ligase ligand conjugate, Pomalidomide-6-2-2-6-I, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader

Poma-6-2-2-6-I

1835705-70-8