ChemicalBook > CAS DataBase List > Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
- Product Name
- Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
- CAS No.
- 2225940-47-4
- Chemical Name
- Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
- Synonyms
- Pomalidomide-C3-COOH;DUN 40474;Poma-C3-COOH;Thalidomide-NH-C3-COOH;Thalidomide-4-NH-C3-COOH;Pomalidomide 4'-alkylC3-acid;4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoic acid;Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-;Butanoic acid, 4[[2(2,6dioxo3piperidinyl)2,3dihydro1,3dioxo1Hisoindol4yl]amino],Butanoic acid, 4 [[2 (2,6 dioxo 3 piperidinyl) 2,3 dihydro 1,3 dioxo 1H isoindol 4 yl]amino;4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
- CBNumber
- CB58094242
- Molecular Formula
- C17H17N3O6
- Formula Weight
- 359.33
- MOL File
- 2225940-47-4.mol
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Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Property
- storage temp.
- 2-8°C
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 901500
- Product name
- Pomalidomide-C3-CO2H
- Purity
- ≥95%
- Packaging
- 50MG
- Price
- $633
- Updated
- 2023/06/20
Iris Biotech GmbH
- Product number
- PTC1100
- Product name
- Pomalidomide-C3-COOH
- Packaging
- 50mg
- Price
- $432
- Updated
- 2021/12/16
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Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Chemical Properties,Usage,Production
Uses
Protein degrader builiding block Pomalidomide-C3-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
storage
Store at -20°C
Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Preparation Products And Raw materials
Raw materials
Preparation Products
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Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Suppliers
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View Lastest Price from Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- Pomalidomide-C3-COOH 2225940-47-4
- Price
- US $0.00/mg
- Min. Order
- 50mg
- Purity
- >95.00%
- Supply Ability
- 50mg
- Release date
- 2024-04-01
2225940-47-4, Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-Related Search:
E3 ligase Ligand-Linker Conjugates 49
Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid
Pomalidomide-C6-PEG3-butyl iodide
E3 ligase Ligand-Linker Conjugates 55
1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
Pomalidomide-6-2-2-6-N3
Pomalidomide-amido-C1-Br
Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
POMALIDOMIDE-C9-CO2H
4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
Pomalidomide-C3-NH2
Pomalidomide-C6-NH2?hydrochloride
Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-