Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-

Product Name: Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
CAS No.: 2225940-47-4
Chemical Name: Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
Synonyms: Pomalidomide-C3-COOH;DUN 40474;Poma-C3-COOH;Thalidomide-NH-C3-COOH;Thalidomide-4-NH-C3-COOH;Pomalidomide 4'-alkylC3-acid;Pomalidomide-C₃-CO₂H;4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid;4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoic acid;Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
CBNumber: CB58094242
Molecular Formula: C17H17N3O6
Formula Weight: 359.33
MOL File: 2225940-47-4.mol

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Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Property

storage temp.: 2-8°C
form: powder or crystals
color: Light green to green

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 901500
Product name: Pomalidomide-C3-CO2H
Purity: ≥95%
Packaging: 50MG
Price: $310.5
Updated: 2025/07/31

Iris Biotech GmbH

Product number: PTC1100
Product name: Pomalidomide-C3-COOH
Packaging: 50mg
Price: $432
Updated: 2021/12/16

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Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-C₃-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reactivity: amine reactive
reagent type: ligand-linker conjugate

storage

Store at -20°C

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Suppliers

China 53 India 1 United States 4 Global 58

Tianjin Qige Technology Co., Ltd.

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Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
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Sigma-Aldrich

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Shanghai YuanYe Biotechnology Co., Ltd.

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BioPharmaMatrix,Inc.

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Xi'an Confluore Biological Technology Co., Ltd.

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Henan Alfachem Co.,Ltd.

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Alfa Chemistry

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View Lastest Price from Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Pomalidomide-C3-COOH 2225940-47-4
Price: US $0.00/mg
Min. Order: 50mg
Purity: >95.00%
Supply Ability: 50mg
Release date: 2024-04-01

2225940-47-4, Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-Related Search:

E3 ligase Ligand-Linker Conjugates 49 Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid Pomalidomide-C6-PEG3-butyl iodide E3 ligase Ligand-Linker Conjugates 55 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Pomalidomide-6-2-2-6-N3 Pomalidomide-amido-C1-Br Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl POMALIDOMIDE-C9-CO2H 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Pomalidomide-C3-NH2 Pomalidomide-C6-NH2?hydrochloride Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-

Pomalidomide-C3-COOH

DUN 40474

4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoic acid

Butanoic acid, 4[[2(2,6dioxo3piperidinyl)2,3dihydro1,3dioxo1Hisoindol4yl]amino],Butanoic acid, 4 [[2 (2,6 dioxo 3 piperidinyl) 2,3 dihydro 1,3 dioxo 1H isoindol 4 yl]amino

Thalidomide-NH-C3-COOH

4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader

Thalidomide-4-NH-C3-COOH

Poma-C3-COOH

Pomalidomide 4'-alkylC3-acid

4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid

Pomalidomide-C<sub>3</sub>-CO<sub>2</sub>H

4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoic acid , Pomalidomide 4'-alkylC3-acid

2225940-47-4