E3 ligase Ligand-Linker Conjugates 55
- Product Name
- E3 ligase Ligand-Linker Conjugates 55
- CAS No.
- 2328070-52-4
- Chemical Name
- E3 ligase Ligand-Linker Conjugates 55
- Synonyms
- Pomalidomide-amido-PEG3-C2-NH2;Cereblon Ligand-Linker Conjugates 22;E3 ligase Ligand-Linker Conjugates 55;3-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]propanamide;3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]propanamide;Propanamide, 3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;3-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide?, Pomalidomide-amido-PEG3-C2-NH2
- CBNumber
- CB36127050
- Molecular Formula
- C22H28N4O8
- Formula Weight
- 476.48
- MOL File
- 2328070-52-4.mol
E3 ligase Ligand-Linker Conjugates 55 Property
- Boiling point:
- 764.7±60.0 °C(Predicted)
- Density
- 1.388±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- Solid
- pka
- 10.69±0.40(Predicted)
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
E3 ligase Ligand-Linker Conjugates 55 Chemical Properties,Usage,Production
Uses
Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].
IC 50
Cereblon
References
[1] Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. DOI:10.1021/acs.jmedchem.8b01826
E3 ligase Ligand-Linker Conjugates 55 Preparation Products And Raw materials
Raw materials
Preparation Products
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