ChemicalBook > CAS DataBase List > E3 ligase Ligand-Linker Conjugates 55
E3 ligase Ligand-Linker Conjugates 55
- Product Name
- E3 ligase Ligand-Linker Conjugates 55
- CAS No.
- 2328070-52-4
- Chemical Name
- E3 ligase Ligand-Linker Conjugates 55
- Synonyms
- Pomalidomide-amido-PEG3-C2-NH2;Cereblon Ligand-Linker Conjugates 22;E3 ligase Ligand-Linker Conjugates 55;3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]propanamide;Propanamide, 3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;3-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide?, Pomalidomide-amido-PEG3-C2-NH2
- CBNumber
- CB36127050
- Molecular Formula
- C22H28N4O8
- Formula Weight
- 476.48
- MOL File
- 2328070-52-4.mol
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E3 ligase Ligand-Linker Conjugates 55 Property
- Boiling point:
- 764.7±60.0 °C(Predicted)
- Density
- 1.388±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- Solid
- pka
- 10.69±0.40(Predicted)
- color
- Off-white to light yellow
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E3 ligase Ligand-Linker Conjugates 55 Chemical Properties,Usage,Production
Uses
Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].
IC 50
Cereblon
References
[1] Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. DOI:10.1021/acs.jmedchem.8b01826
E3 ligase Ligand-Linker Conjugates 55 Preparation Products And Raw materials
Raw materials
Preparation Products
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2328070-52-4, E3 ligase Ligand-Linker Conjugates 55Related Search:
E3 ligase Ligand-Linker Conjugates 49
Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid
Pomalidomide-C6-PEG3-butyl iodide
POMALIDOMIDE-C9-CO2H
Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
Pomalidomide-6-2-2-6-N3
Pomalidomide-amido-C1-Br
Pomalidomide-C6-NH2?hydrochloride
Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-