Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide

Product Name: Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
CAS No.: 1835705-76-4
Chemical Name: Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
Synonyms: Pomalidomide-6-5-6-I;Pomalidomide-C?-PEG?-C?-PEG?-butyl iodide;Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide;N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-6-({5-[(6-iodohexyl)oxy]pentyl}oxy)hexanamide;Hexanamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-6-[[5-[(6-iodohexyl)oxy]pentyl]oxy]-;Crosslinker?E3 Ligase ligand conjugate, Pomalidomide-6-5-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-6-((5-((6-iodohexyl)oxy)pentyl)oxy)hexanamide, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
CBNumber: CB95430588
Molecular Formula: C30H42IN3O7
Formula Weight: 683.57
MOL File: 1835705-76-4.mol

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Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Property

Boiling point:: 809.7±65.0 °C(Predicted)
Density: 1.412±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 10.69±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 906050
Product name: Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
Purity: ≥95%
Packaging: 50MG
Price: $558
Updated: 2023/06/20

Iris Biotech GmbH

Product number: PTC1710
Product name: Pomalidomid-C6-PEG1-C3-PEG1-butyl-I
Packaging: 50mg
Price: $634.5
Updated: 2021/12/16

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Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-C₆-PEG₁-C₃-PEG₁-Butyl Iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Preparation Products And Raw materials

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View Lastest Price from Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Pomalidomide-6-5-6-I 1835705-76-4
Price: US $0.00/mg
Min. Order: 100mg
Purity: >95.00%
Supply Ability: 100mg
Release date: 2024-04-01

1835705-76-4, Pomalidomide-C6-PEG1-C3-PEG1-butyl iodideRelated Search:

E3 ligase Ligand-Linker Conjugates 49 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl E3 ligase Ligand-Linker Conjugates 55 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Pomalidomide-6-2-2-6-N3 Pomalidomide-amido-C1-Br Pomalidomide-C6-NH2?hydrochloride Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Pomalidomide-C6-PEG3-butyl iodide POMALIDOMIDE-C9-CO2H

Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide

Hexanamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-6-[[5-[(6-iodohexyl)oxy]pentyl]oxy]-

Pomalidomide-6-5-6-I

Crosslinker?E3 Ligase ligand conjugate, Pomalidomide-6-5-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-6-((5-((6-iodohexyl)oxy)pentyl)oxy)hexanamide, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader

Pomalidomide-C?-PEG?-C?-PEG?-butyl iodide

N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-6-({5-[(6-iodohexyl)oxy]pentyl}oxy)hexanamide

1835705-76-4

C30H42IN3O7