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Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide

Product Name
Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
CAS No.
1835705-76-4
Chemical Name
Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
Synonyms
Pomalidomide-6-5-6-I;Pomalidomide-C?-PEG?-C?-PEG?-butyl iodide;Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide;N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-6-({5-[(6-iodohexyl)oxy]pentyl}oxy)hexanamide;Hexanamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-6-[[5-[(6-iodohexyl)oxy]pentyl]oxy]-;Crosslinker?E3 Ligase ligand conjugate, Pomalidomide-6-5-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-6-((5-((6-iodohexyl)oxy)pentyl)oxy)hexanamide, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
CBNumber
CB95430588
Molecular Formula
C30H42IN3O7
Formula Weight
683.57
MOL File
1835705-76-4.mol
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Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Property

Boiling point:
809.7±65.0 °C(Predicted)
Density 
1.412±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
10.69±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
906050
Product name
Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
Purity
≥95%
Packaging
50MG
Price
$558
Updated
2023/06/20
Iris Biotech GmbH
Product number
PTC1710
Product name
Pomalidomid-C6-PEG1-C3-PEG1-butyl-I
Packaging
50mg
Price
$634.5
Updated
2021/12/16
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Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-C6-PEG1-C3-PEG1-Butyl Iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Preparation Products And Raw materials

Raw materials

Preparation Products

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Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Suppliers

China 8 United States 1 Global 9
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Xi'an Confluore Biological Technology Co., Ltd.
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
Country
China
ProdList
4824
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58
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
Email
1927928688@qq.com
Country
China
ProdList
1388
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58
Shaanxi borno biotechnology co., LTD
Tel
+86-13759708231
Email
asherw9@hotmail.com
Country
China
ProdList
2350
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58
Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
Country
China
ProdList
18478
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58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054 13417589054
Email
trendseenbio@gmail.com
Country
China
ProdList
9470
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58
Xian confluore Biological Technology Co., Ltd.
Tel
+86-15680926068 +86-15680926068
Email
1924344760@confluore.cn
Country
China
ProdList
2995
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58
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View Lastest Price from Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Pomalidomide-6-5-6-I 1835705-76-4
Price
US $0.00/mg
Min. Order
100mg
Purity
>95.00%
Supply Ability
100mg
Release date
2024-04-01

1835705-76-4, Pomalidomide-C6-PEG1-C3-PEG1-butyl iodideRelated Search:

E3 ligase Ligand-Linker Conjugates 49 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl E3 ligase Ligand-Linker Conjugates 55 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Pomalidomide-6-2-2-6-N3 Pomalidomide-amido-C1-Br Pomalidomide-C6-NH2?hydrochloride Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Pomalidomide-C6-PEG3-butyl iodide POMALIDOMIDE-C9-CO2H

  • Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
  • Hexanamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-6-[[5-[(6-iodohexyl)oxy]pentyl]oxy]-
  • Pomalidomide-6-5-6-I
  • Crosslinker?E3 Ligase ligand conjugate, Pomalidomide-6-5-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-6-((5-((6-iodohexyl)oxy)pentyl)oxy)hexanamide, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
  • Pomalidomide-C?-PEG?-C?-PEG?-butyl iodide
  • N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-6-({5-[(6-iodohexyl)oxy]pentyl}oxy)hexanamide
  • 1835705-76-4
  • C30H42IN3O7