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BI 3663

Product Name
BI 3663
CAS No.
2341740-84-7
Chemical Name
BI 3663
Synonyms
BI 3663);BI-3663 (BI3663;N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-3-{2-[2-(2-{[3-methoxy-4-({4-[(3-oxo-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl}amino)phenyl]formamido}ethoxy)ethoxy]ethoxy}propanamide;Benzamide, 4-[[4-[(2,3-dihydro-3-oxo-1H-inden-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-N-[2-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethyl]-3-methoxy-
CBNumber
CB74844551
Molecular Formula
C44H42F3N7O12
Formula Weight
917.84
MOL File
2341740-84-7.mol
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BI 3663 Property

Density 
1.456±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 300 mg/mL (326.85 mM; Need ultrasonic)
form 
Solid
pka
10.69±0.40(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0087090
Product name
BI-3663
Purity
98.14%
Packaging
1mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0087090
Product name
BI-3663
Purity
98.14%
Packaging
5mg
Price
$1400
Updated
2021/12/16
ChemScene
Product number
CS-0087090
Product name
BI-3663
Purity
98.14%
Packaging
10mg
Price
$2400
Updated
2021/12/16
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BI 3663 Chemical Properties,Usage,Production

Uses

BI-3663 is a highly selective PTK2/FAK PROTAC (DC50=30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 (HY-124625) linked to Pomalidomide (HY-10984) with a linker[1]. Anti-cancer activity[1].

IC 50

PTK2/FAK: 18 nM (IC50); Cereblon

References

[1] Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. DOI:10.1021/acs.jmedchem.8b01826

BI 3663 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI 3663 Suppliers

China 16 United States 4 Global 20
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
Email
1927928688@qq.com
Country
China
ProdList
1615
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988941452
Fax
QQ：3283937693
Email
YN_research@163.com
Country
China
ProdList
3011
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58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054;
Email
trendseenbio@gmail.com
Country
China
ProdList
9069
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58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5929
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58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
5002
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58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
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Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
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Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
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58
Guangzhou Weisheng Biotechnology Co., Ltd.
Tel
17765667235
Country
CHINA
ProdList
129
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58
Guangzhou Yiran Biotechnology Co., Ltd.
Tel
15571990006
Country
CHINA
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141
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58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
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Email
info@zzsrm.com
Country
CHINA
ProdList
6650
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58

2341740-84-7, BI 3663Related Search:

Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG1-piperazine Pomalidomide-PEG2-butyl iodide Pomalidomide-C6-PEG3-butyl iodide Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide

  • BI 3663)
  • BI-3663 (BI3663
  • Benzamide, 4-[[4-[(2,3-dihydro-3-oxo-1H-inden-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-N-[2-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethyl]-3-methoxy-
  • N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-3-{2-[2-(2-{[3-methoxy-4-({4-[(3-oxo-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl}amino)phenyl]formamido}ethoxy)ethoxy]ethoxy}propanamide
  • 2341740-84-7