FES antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human

Background

Fes/Fps and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. Fes and Fer contain a central Src homology-2 domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. Fes/Fps was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. Mutations may activate the Fps kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-Fes protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.

References

[1] Smithgall, T.E. et al. (1998) Crit Rev Oncog 9, 43-62.
[2] Greer, P. (2002) Nat Rev Mol Cell Biol 3, 278-89.
[3] Sangrar, W. et al. (2005) Cancer Res 65, 3518-22.
[4] Ley, T.J. et al. (2003) Proc Natl Acad Sci U S A 100, 14275-80.
[5] Delfino, F.J. et al. (2006) J Biol Chem 281, 8829-35.

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