KRAS Antibody Usage And Synthesis

Source

Rabbit

Applications

KRAS antibody has been tested by ELISA, Western blot analysis, ICC/IF and Flow cytometry to assure specificity and reactivity.

Reactivity

Human;Mouse;Rat

Immunogen

Anti-human KRAS mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human KRAS protein 1-186 amino acids purified from E. coli.

Background

Kirsten Rat Sarcoma Viral Oncogene, Isoform 2A (KRAS-2A) belongs to the small GTPase superfamily. The KRAS-2A protein is involved in a variety of malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Ras family members impact cell growth and differentiation events in a subcellular membrane compartmentalization-based signaling system under normal conditions. Oncogenic Ras can deregulate processes which control both cell proliferation and apoptosis.

References

[1] Boguski, M.S. and McCormick, F. (1993) Nature 366, 643-54.
[2] Avruch, J. et al. (1994) Trends Biochem Sci 19, 279-83.
[3] Buday, L. and Downward, J. (1993) Cell 73, 611-20.
[4] Huang, D.C. et al. (1993) Mol Cell Biol 13, 2420-31.
[5] Bos, J.L. (1989) Cancer Res 49, 4682-9.
[6] Ma, J. and Karplus, M. (1997) J Mol Biol 274, 114-31.

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