RALA antibody Usage And Synthesis

Source

Rabbit

Applications

The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Recommended dilution range for Western blot analysis is 1:500 ~ 1:2000. Recommended starting dilution is 1:1000.

Reactivity

Human;Monkey

Immunogen

Anti-human RALA mAb, clone PAT41D5A, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human RALA protein 1-203 amino acids purified from E. coli..

Background

Ras-related protein Ral-A (RALA) is a member of the small GTPase superfamily, Ras family of proteins. RALA mediates a distinct downstream signaling pathway from Ras which facilitates cellular transformation. Furthermore, RALA is thought to be involved in various signaling cascades, including regulation of the cytoskeleton, vesicle trafficking, and endocytosis.

References

[1] Li, G. et al. (2007) J Neurosci 27, 190-202.
[2] van Dam, E.M. and Robinson, P.J. (2006) Int J Biochem Cell Biol 38, 1841-7.
[3] Camonis, J.H. and White, M.A. (2005) Trends Cell Biol 15, 327-32.
[4] Lim, K.H. et al. (2005) Cancer Cell 7, 533-45.
[5] Chien, Y. et al. (2006) Cell 127, 157-70.
[6] Oxford, G. et al. (2005) Cancer Res 65, 7111-20.
[7] Lim, K.H. et al. (2006) Curr Biol 16, 2385-94.

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