RRAS antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Monkey

Background

R-Ras, a member of the small GTPase family, is homologous to H-, K- and N-Ras, but does not activate MAP kinase pathways and is only weakly oncogenic. Instead, R-Ras is engaged in integrin activation. The effector loop and the carboxy-terminal proline-rich and prenylation sites of R-Ras are critical for integrin activation. Phosphorylation by EphB2 receptor tyrosine kinase and Src at Tyr66 of R-Ras suppresses integrin activity.

References

[1] Self, A. J. et al. (2001) J. Cell Sci. 114, 1357-1366.
[2] Zhang, Z. et al. (1996) Cell 85, 61-69.
[3] Oertli, B. et al. (2000) Oncogene 19, 4961-4969.
[4] Wang, B. et al. (2000) J Biol Chem 275, 5222-7.
[5] Zou, J.X. et al. (1999) Proc Natl Acad Sci U S A 96, 13813-8.
[6] Zou, J.X. et al. (2002) J Biol Chem 277, 1824-7.

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