TYK2 Antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human

Background

Tyk2 is a member of the Jak family of protein tyrosine kinases. It associates with and is activated by receptors for many cytokines including IL-13, the IL-6 family, IL-10, and IFN-α and β. Following ligand binding, Tyk2 is activated by phosphorylation of Tyr1054 and/or Tyr1055. Tyk2 is required for the tyrosine phosphorylation of Stat3 in the IFN-β signaling cascade.

References

[1] Velazquez, L. et al. (1995) J. Biol. Chem. 270, 3327-34.
[2] Stahl, N. et al. (1994) Science 263, 92-5.
[3] Leonard, W.J. (1998) Annu. Rev. Immunol. 16, 293-322.
[4] Gauzzi, M.C. et al. (1996) J Biol Chem 271, 20494-500.
[5] Rani, M.R. et al. (1999) J. Biol. Chem. 274, 32507-11.

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