SB 4 Chemical Properties

Melting point:

70-72 °C

Boiling point:

444.2±47.0 °C(Predicted)

Density 

1.57±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in DMSO

form 

Solid

pka

0.92±0.10(Predicted)

color 

White to light yellow

SB 4 Usage And Synthesis

Uses

SB 4 (Eticovo) is a potent and selective agonist of bone morphogenetic protein 4 (BMP4) signaling.

Biological Activity

Sb4 is a cell penetrant, potent bone morphogenetic protein (BMP) signaling agonist th at rapidly activate BMP in human renal cells (HEK293). Sb4 activates BMP by stabilization of intracellular p-SMAD-1/5/9. Apparently activation of the BMP pathway by sb4 cannot be reversed by inhibition of Noggin or type I BMP kinase inhibitors

storage

Store at -20°C